{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:47:49Z","timestamp":1777589269268,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Deputy of Research, School of Dentistry, Shahid Beheshti University of Medical Sciences","award":["5118-5120"],"award-info":[{"award-number":["5118-5120"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Chronic periodontitis (CP) is a multifactorial disease and the most common type of periodontitis mainly caused by microbial plaque. CP can be brought on by, and progresses with, insufficient oral hygiene, and environmental and genetic susceptibilities. The aim of the present study was to investigate the association between <jats:italic>interleukin (IL)\u20102<\/jats:italic> (T\u2010330G), <jats:italic>IL\u201016<\/jats:italic> (T\u2010295C), and <jats:italic>IL\u201017<\/jats:italic> (A\u20107383G) gene polymorphisms and the susceptibility to CP in an Iranian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010nine cases diagnosed with CP and 75 matched healthy controls engaged in the present study. 3\u00a0cc peripheral blood samples were obtained for DNA isolation. Genotype analysis was performed using restriction fragment length polymorphism polymerase chain reaction. Genotype distribution and allele frequencies within groups were compared using \u03c7<jats:sup>2<\/jats:sup>\u2010test, and logistic regression analysis was used to recognize the independent relation between the disease and the absence or presence of alleles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no polymorphism in <jats:italic>IL\u20102<\/jats:italic> (T\u2010330G) among our patients, and the TT genotype was present in both study groups. Moreover, none of the studied genotypes and alleles of <jats:italic>IL\u201016<\/jats:italic> (T\u2010295C) and <jats:italic>IL\u201017<\/jats:italic> (A\u20107383G) was significantly associated with CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study demonstrated no association between <jats:italic>IL\u20102<\/jats:italic> (T\u2010330G), <jats:italic>IL\u201016<\/jats:italic> (T\u2010295C), and <jats:italic>IL\u201017<\/jats:italic> (A\u20107383G) genotypes and CP in an Iranian population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12319","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T08:46:53Z","timestamp":1517820413000},"source":"Crossref","is-referenced-by-count":17,"title":["Interleukin\u20102, \u201016, and \u201017 gene polymorphisms in Iranian patients with chronic 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