{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:35:20Z","timestamp":1753878920009,"version":"3.41.2"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present cross\u2010sectional study was to investigate the effects of bisphosphonates (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>), prescribed for osteoporosis, on jawbones using multidetector computed tomography (<jats:styled-content style=\"fixed-case\">MDCT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010three women who had dual\u2010energy X\u2010ray absorptiometry examination were scanned by <jats:styled-content style=\"fixed-case\">MDCT<\/jats:styled-content>. Both the cortical and the trabecular parts of the alveolar and the cortical bones were compared between <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> users and non\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> users using a number of radiological measurements. Linear regression was used for the statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cortical part of the basal bone of the mandible revealed a significant increase in the <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> group (.001\u00a0&gt;\u00a0<jats:italic>P<\/jats:italic>\u2010value\u00a0\u2264\u00a0.026) after using <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> for 5\u00a0years. No alternations were observed in the trabecular part of the basal bone or in the cortical or trabecular parts of the alveolar bone over the same duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> as a treatment for osteoporosis for 5\u00a0years increased the thickness of the cortex of the basal bone of the mandible, as detected by <jats:styled-content style=\"fixed-case\">MDCT<\/jats:styled-content>. The other parts of the jawbones showed no influence by <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> for such a purpose, as detected on <jats:styled-content style=\"fixed-case\">MDCT<\/jats:styled-content> images. Accordingly, models (equations) for predicting the alternations in the inferior cortex of the mandible induced by <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> therapy during osteoporosis have been suggested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12332","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T04:50:38Z","timestamp":1522039838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Detecting the effect of bisphosphonates during osteoporosis treatment on jawbones using multidetector computed tomography: The <scp>OSTEOSYR<\/scp> project"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-5818","authenticated-orcid":false,"given":"Imad","family":"Barngkgei","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Faculty of Dentistry Syrian Private University  Damascus Syria"},{"name":"Department of Oral Medicine Faculty of Dentistry Damascus University  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razan","family":"Khattab","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Damascus University  Damascus Syria"},{"name":"Department of Periodontology Faculty of Dentistry Alsham Private University  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.6.785"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. 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