{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:13:41Z","timestamp":1784402021875,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Alendronate (ALN) has antiresorptive and osteostimulative properties. The major component of aloe vera (AV) gel is acemannan, which has been found to have osteogenic properties. The aim of the present study is to explore the effectiveness of 1% ALN and AV gel as an adjunct to scaling and root planing (SRP) in chronic periodontitis patients with class II furcation defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety volunteers were randomly assigned to three treatment groups: (a) SRP plus placebo gel; (b) SRP plus 1% ALN gel; and (c) SRP plus AV gel. Clinical and radiographic parameters were recorded at baseline and at 6 and 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean probing depth reduction and relative horizontal clinical attachment level (CAL) and relative vertical CAL gains were greater in the ALN group than in the AV and placebo groups at 6 and 12\u00a0months. Furthermore, a significantly greater mean percentage of defect depth reduction (DDR) was found in the ALN group (38.09\u00a0\u00b1\u00a09.53, 44.86\u00a0\u00b1\u00a06.29) than the AV groups (11.94\u00a0\u00b1\u00a015.10, 14.59\u00a0\u00b1\u00a025.49) at 6 and 12\u00a0months, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ALN showed significant improvement in all clinical parameters, along with greater DDR, compared to AV in the treatment of class II furcation defects as an adjunct to SRP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12334","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T04:30:05Z","timestamp":1525321805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["One percent alendronate and aloe vera gel local host modulating agents in chronic periodontitis patients with class II furcation defects: A randomized, controlled clinical trial"],"prefix":"10.1111","volume":"9","author":[{"given":"Sahu","family":"Ipshita","sequence":"first","affiliation":[{"name":"Department of Periodontology Government Dental College and Research Institute  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida G.","family":"Kurian","sequence":"additional","affiliation":[{"name":"Department of Periodontology Government Dental College and Research Institute  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Dileep","sequence":"additional","affiliation":[{"name":"Department of Periodontology Government Dental College and Research Institute  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shatrughan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medicine  Employee's State Insurance Postgraduate Institute of Medical Science and Research  Bangalore Karnataka 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