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PubMed, Scopus, Embase and Google Scholar were searched. The filter \u201cEnglish\u201d was used. The timeframe searched was 1980\u2010 2015. The<jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content>flow chart was used. Data were extracted using the Joanna Briggs Institute standardized data extraction form and transferred to<jats:styled-content style=\"fixed-case\">SPSS<\/jats:styled-content>version 22 for analysis. The systematic review of 97 studies (70 low bias risk) showed that the prevalence of<jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>continue to be significant in developing countries. Globally and through all the decades, oral candidiasis remained the most commonly encountered<jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>, including among patients on antiretroviral therapy (<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>) (26.2%). Hairy leukoplakia was more prevalent in Europe and America compared with Africa and Asia. Oral warts were reported more often in studies on patients receiving<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>. Interestingly, salivary gland disease decreased in the developed world and increased in developing countries over time. Despite the changing pattern of these conditions over time, there is no evidence that the<jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>have become of less significance globally. 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