{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:45:56Z","timestamp":1791215156653,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to investigate the tissue generated after regenerative endodontic procedure (<jats:styled-content style=\"fixed-case\">REP<\/jats:styled-content>) in the root canal space of an immature mandibular second premolar with pulp necrosis and chronic apical abscess using cone\u2010beam computed tomographic (<jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content>) and histological methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">REP<\/jats:styled-content> was performed in an immature mandibular second premolar. At the 3\u2010year follow up, <jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content> scans were taken to evaluate the outcome of treatment. As the tooth was not restorable to function, it was extracted and processed for histological examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content> showed a reduction in size of the periradicular radiolucency, with a marginal increase in root length. Apical closure and thickening of the root canal walls were apparent. Histologically, the root canal space was filled with minimally\u2010inflamed fibrous connective tissue. Some cementum\u2010like mineralized connective tissue was evident on the internal canal walls. The apical third showed cementum\u2010like deposits at the apex and the outer canal walls, without dentin formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study of a structurally\u2010failed tooth with prior <jats:styled-content style=\"fixed-case\">REP<\/jats:styled-content> demonstrates that the tissue formed within the root canal space was fibrous connective tissue with cementum\u2010like deposition in the canal space. No evidence of dentin\u2010 or pulp\u2010like tissue was found.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12352","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T10:27:36Z","timestamp":1531132056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cone\u2010beam computed tomographic and histological investigation of regenerative endodontic procedure in an immature mandibular second premolar with chronic apical abscess"],"prefix":"10.1111","volume":"9","author":[{"given":"Heeresh","family":"Shetty","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Nair Hospital Dental College  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishir","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics A.B. 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