{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:14:31Z","timestamp":1792808071656,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Council for Technological Development","award":["443004\/2014-5"],"award-info":[{"award-number":["443004\/2014-5"]}]},{"name":"National Council for Technological Development","award":["455173\/2014-1"],"award-info":[{"award-number":["455173\/2014-1"]}]},{"name":"S\u00e3o Paulo State Research Support Foundation","award":["2015\/07727-9"],"award-info":[{"award-number":["2015\/07727-9"]}]},{"name":"S\u00e3o Paulo State Research Support Foundation","award":["2017\/07778-8"],"award-info":[{"award-number":["2017\/07778-8"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to describe the salivary shedding of human herpesviruses (<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>) in renal transplant recipients and to observe the oral manifestations in this group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective case\u2010control study was conducted with a study group of 20 renal transplant recipients and a control group of 20 non\u2010transplanted, immunocompetent individuals. Clinical examination evaluated the presence of drug\u2010induced gingival overgrowth (<jats:styled-content style=\"fixed-case\">DIGO<\/jats:styled-content>), salivary flow, and caries. Stimulated saliva was collected from both groups, with <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content> being detected by using real\u2010time polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the study group was 45.90\u00a0\u00b1\u00a09.89\u00a0years, with 55% (11\/20) being female, 60% (12\/20) being Caucasian, 65% (13\/20) having a deceased donor, and 70% (14\/20) having used tacrolimus as the main immunosuppressive drug. Renal transplant recipients had shedding of more herpesviruses compared to the control group, with the exception of <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20107. Statistical significance was found for herpes simplex virus\u20101 (<jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>\u20101) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.017) and cytomegalovirus (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.035). <jats:styled-content style=\"fixed-case\">DIGO<\/jats:styled-content> was observed in seven patients (35%), with 35% (7\/20) presenting with decreased salivary flow and four (20%) reporting xerostomia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Renal transplant recipients excreted herpesviruses more often than control individuals, especially <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>\u20101. Decreased salivary flow and xerostomia were more frequent in patients who used tacrolimus, whereas those who used cyclosporine had more cases of <jats:styled-content style=\"fixed-case\">DIGO<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12356","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T03:55:40Z","timestamp":1533009340000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Salivary shedding of herpesviruses in renal transplant recipients"],"prefix":"10.1111","volume":"9","author":[{"given":"Dmitry Jos\u00e9 de Santana","family":"Sarmento","sequence":"first","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens","family":"Caliento","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amabile Oliveira de","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia Regina","family":"Tozetto\u2010Mendoza","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine of S\u00e3o Paulo Univerity of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Adriano de Oliveira","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1842-9521","authenticated-orcid":false,"given":"Paulo Henrique","family":"Braz\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Institute of Tropical Medicine of S\u00e3o Paulo Univerity of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Gallottini","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,30]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"ABTO \u2010 Brazilian Association of Organ Transplantation. 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