{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T09:37:45Z","timestamp":1768729065336,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Invest & Clin Dent"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Silver diammine fluoride (SDF<\/jats:styled-content>) is an anticaries agent that binds to tooth tissue. The aim of the present study was investigate the dose\u2010response effect of SDF<\/jats:styled-content> on demineralized dentine in basal medium mucin (BMM<\/jats:styled-content>) saliva substitute and human saliva.<\/jats:p><\/jats:sec>Methods<\/jats:title>Dentine discs stored in saliva substitute, BMM<\/jats:styled-content>, and human unstimulated whole saliva (UWS<\/jats:styled-content>) were chemically demineralized, and 10\u00a0\u03bcL of 10 wt%, 24 wt%, or 38 wt% SDF<\/jats:styled-content> was applied and then stored in its respective saliva (BMM<\/jats:styled-content> or UWS<\/jats:styled-content>) for 5\u00a0days. Dentine disc samples were digested in 70% HNO3<\/jats:sub>, and silver was quantitatively detected by inductively coupled plasma mass spectroscopy.<\/jats:p><\/jats:sec>Results<\/jats:title>For both the BMM<\/jats:styled-content> and UWS<\/jats:styled-content> groups, the presence of silver increased proportionally with increasing concentrations of SDF<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). For the 38 wt% SDF<\/jats:styled-content> application, the mean absorption percentage of silver in dentine was 3.90% for the UWS<\/jats:styled-content> group and 6.61% for the BMM<\/jats:styled-content> group. The BMM<\/jats:styled-content> group was found to yield a significantly higher amount of silver compared to UWS<\/jats:styled-content> at 10 wt% and 38 wt% SDF<\/jats:styled-content> application (\u03b1\u00a0=\u00a00.05); 38 wt% SDF<\/jats:styled-content> interacts more with BMM<\/jats:styled-content> with higher silver deposition than UWS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The amount of silver found in dentine was in proportion to the concentration of SDF<\/jats:styled-content>. Extrapolation of in vitro investigations using artificial saliva for SDF<\/jats:styled-content> tooth interactions should be interpreted with caution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12382","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T15:31:52Z","timestamp":1545060712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Silver deposition on demineralized dentine surface dosed by silver diammine fluoride with different saliva"],"prefix":"10.1111","volume":"10","author":[{"given":"Jing\u2010Yuan","family":"Peng","sequence":"first","affiliation":[{"name":"Medical School of Nanjing University Nanjing Stomatological Hospital Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James K. H.","family":"Tsoi","sequence":"additional","affiliation":[{"name":"Dental Materials Science Faculty of Dentistry The University of Hong Kong Prince Philip Dental Hospital Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka P.","family":"Matinlinna","sequence":"additional","affiliation":[{"name":"Dental Materials Science Applied Oral Sciences Faculty of Dentistry The University of Hong Kong Prince Philip Dental Hospital Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4077-4716","authenticated-orcid":false,"given":"Michael G.","family":"Botelho","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Faculty of Dentistry The University of Hong Kong Prince Philip Dental Hospital Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2012.03.009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034508329406"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-12-60"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2011.10.009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2008.02.013"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2011.01149.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijadhadh.2016.06.011"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(01)00060-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2008.00575.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0109-5641(90)90048-J"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpr.2002.121238"},{"key":"e_1_2_6_13_1","unstructured":"PengJY.Morphological and Quantitative Analysis of Silver Compounds on Demineralised Dentine in Saliva Substitutes (Thesis).The University of Hong Kong Pokfulam Hong Kong SAR 2013.https:\/\/hub.hku.hk\/bitstream\/10722\/197082\/2\/FullText.pdf. 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