{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:18:07Z","timestamp":1779167887539,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T00:00:00Z","timestamp":1547942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to assess and compare the clinical efficacy of local probiotic <jats:italic>Lactobacillus reuteri<\/jats:italic> (<jats:italic>L.\u00a0reuteri<\/jats:italic>) and systemic antibiotics as adjunct to scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) in the treatment of chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty systemically\u2010healthy participants (15 probiotic and 15 antibiotic), clinically diagnosed with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>, were enrolled. All patients underwent <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>. Adjunctive probiotics were administered twice daily for 3\u00a0months, whereas a combination of amoxicillin and metronidazole were given three times daily for 7\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intragroup analysis showed statistically\u2010significant improvement in all clinical parameters: plaque index, bleeding on probing, periodontal pocket depth, and clinical attachment level gain at each follow\u2010up visit. However, intergroup comparison of clinical periodontal parameters did not show statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The adjunctive use of <jats:italic>L.\u00a0reuteri<\/jats:italic> and systemic antibiotics along with <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> showed similar improvement in all clinical periodontal parameters. This indicates that both adjunctive therapeutic agents showed similar efficacy in resolving inflammation and improving periodontal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12393","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T04:14:47Z","timestamp":1548044087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Effect of local probiotic (<i>Lactobacillus reuteri<\/i>) vs systemic antibiotic therapy as an adjunct to non\u2010surgical periodontal treatment in chronic periodontitis"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9088-7877","authenticated-orcid":false,"given":"Sana","family":"Ikram","sequence":"first","affiliation":[{"name":"Department of Oral Biology Faculty of Dentistry Ziauddin University  Karachi 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