{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:07Z","timestamp":1787015527679,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of the present study was to evaluate the effect of non\u2010surgical periodontal therapy (NSPT) on gingival crevicular fluid (GCF) and serum leptin levels and glycemic status in periodontally healthy patients with chronic periodontitis (CP) with and without type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety patients were divided into three groups: periodontally healthy (group 1), CP (group 2) and CP with T2DM (group 3). The groups were evaluated for clinical parameters of probing pocket depth (PPD), clinical attachment level (CAL), plaque index, gingival index, biochemical parameters of GCF, serum leptin levels, and glycemic status pre\u2010 and post\u2010NSPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The baseline PPD and CAL for group 2 was 4.98\u00a0\u00b1\u00a00.49\u00a0mm and 5.35\u00a0\u00b1\u00a00.55\u00a0mm, respectively; for group 3 it was 5.60\u00a0\u00b1\u00a00.38\u00a0mm and 6.01\u00a0\u00b1\u00a00.38\u00a0mm, respectively. There was a considerable reduction in these parameters post\u2010NSPT, with group 2 showing better resolution. Pretreatment serum leptin levels revealed increasing values from group 1 to group 3 and decreasing GCF values from group 3 to group 1, exhibiting an inverse relationship. Group 3 also showed an improvement in glycemic status post\u2010NSPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NSPT was effective in improving clinical parameters, increasing GCF, reducing serum leptin levels, and also improving glycemic status in patients with CP and CP with T2DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jicd.12420","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T02:04:31Z","timestamp":1559873071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of non\u2010surgical periodontal treatment on gingival crevicular fluid and serum leptin levels in periodontally healthy chronic periodontitis and chronic periodontitis patients with type 2 diabetes mellitus"],"prefix":"10.1111","volume":"10","author":[{"given":"Charu R.","family":"Ahuja","sequence":"first","affiliation":[{"name":"Department of Periodontics and Implantology Vidya Sikshan Prasarak Mandal (VSPM) Dental College and Research Centre Nagpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay P.","family":"Kolte","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implantology Vidya Sikshan Prasarak Mandal (VSPM) Dental College and Research Centre Nagpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6386-1671","authenticated-orcid":false,"given":"Rajashri A.","family":"Kolte","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implantology Vidya Sikshan Prasarak Mandal (VSPM) Dental College and Research Centre Nagpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhur","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Narendra Kumar Salve 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