{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T10:31:09Z","timestamp":1777977069417,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T00:00:00Z","timestamp":1561248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to evaluate the association of interleukin\u201017 (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017<\/jats:italic>) A\u2010197G gene polymorphism with chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) in a case\u2010control study, a meta\u2010analysis, and an in silico approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the case\u2010control study, 122 cases with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> and 126 healthy controls were recruited; <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017<\/jats:italic> A\u2010197G genotyping was performed by polymerase chain reaction\u2010restriction fragment length polymorphism. In the meta\u2010analysis, comprehensive literature retrieval was performed on valid databases to identify relevant studies. Bioinformatics tools were employed to investigate the effects of A\u2010197G transition on the promoter region of <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our case\u2010control study revealed a significant association between <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017<\/jats:italic> A\u2010197G transition and <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. The overall meta\u2010analysis revealed significant associations between the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017<\/jats:italic> A\u2010197G polymorphism and <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> risk in homozygote co\u2010dominant and recessive models. The stratified analysis also showed a statistically significant association between the mentioned transition and <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> risk in the Caucasian population. The in silico analysis revealed that the A\u2010197G polymorphism could make changes in protein\u2010binding sites of the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017<\/jats:italic> promoter region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study supports that <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017<\/jats:italic> A\u2010197G transition could be a genetic risk factor for <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. However, further studies with a larger sample size among different ethnicities are required to obtain a more accurate conclusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12424","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T04:44:24Z","timestamp":1561351464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of A\u2010197G polymorphism in interleukin\u201017 gene with chronic periodontitis: Evidence from six case\u2010control studies with a computational biology approach"],"prefix":"10.1111","volume":"10","author":[{"given":"Amir","family":"Farmohammadi","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Medicine Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atefeh","family":"Tavangar","sequence":"additional","affiliation":[{"name":"Department of Oral and 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