{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:50:00Z","timestamp":1791348600488,"version":"4.3.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T00:00:00Z","timestamp":1564185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effectiveness of topical insulin\u2010liposomal gel in aphthous ulcer treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>80 participants with minor aphthous ulcers were randomly divided to receive either topical insulin\u2010liposomal gel or placebo gel (once daily) for 6\u00a0days. Assessment of outcomes included visual analog scale (VAS) for pain (primary outcome), and secondary outcomes included ulcer duration and impact of treatment on quality of life using the Oral Health Impact Profile 14 (OHIP\u201014). Testing of the outcomes was carried out at 1, 2, 3, 4 and 6\u00a0days after treatment for VAS and at 6\u00a0days for OHIP\u201014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For pain scores, the test group showed a significant decrease by time, this was evident from day 1 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001); at day 3, median and interquartile range (IQR) values were 0 (0\u20101). For the placebo group, a non\u2010significant change by time was reported between baseline and day 1; at day 3, the median value was 7 (IQR, 7\u20109). The test group showed significantly lower mean duration than the placebo group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). OHIP\u201014 scores after 6\u00a0days showed that the test group had a significantly lower score than placebo (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Topical insulin\u2010liposomal formulation showed marked effectiveness in management of aphthous ulcers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12437","type":"journal-article","created":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T09:13:46Z","timestamp":1564218826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Topical insulin\u2010liposomal formulation in management of recurrent aphthous ulcers: A randomized placebo\u2010controlled trial"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8169-841X","authenticated-orcid":false,"given":"Naglaa M.","family":"El\u2010Wakeel","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Periodontology, Faculty of Dentistry October University for Modern Sciences and Arts (MSA) Cairo Egypt"},{"name":"Faculty of Dentistry,Al\u2010Azhar University (Girls Branch) Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia M.","family":"Morsi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia M.","family":"Ghorab","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada E.","family":"Yassin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy October University for Modern Sciences and Arts (MSA) Cairo Egypt"},{"name":"Department of Pharmaceutics, Faculty of Pharmacy Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa H. S.","family":"Dawoud","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy October University for Modern Sciences and Arts (MSA) Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51401"},{"key":"e_1_2_7_3_1","first-page":"54","article-title":"Recurrent aphthous stomatitis: a review","volume":"10","author":"Edgar NR","year":"2017","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.09.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51401"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588408X261816"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-10-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12122"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-4804(02)00036-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199802000-00019"},{"issue":"8","key":"e_1_2_7_11_1","first-page":"22","article-title":"A randomized, double\u2010blind, placebo\u2010controlled trial to determine the effects of topical insulin on wound healing","volume":"55","author":"Rezvani O","year":"2009","journal-title":"Ostomy Wound Manage"},{"issue":"1","key":"e_1_2_7_12_1","first-page":"00007","article-title":"The role of insulin in wound healing process: mechanism of action and pharmaceutical applications","volume":"2","author":"AbdelKader DH","year":"2016","journal-title":"J Anal Pharm Res"},{"issue":"6","key":"e_1_2_7_13_1","first-page":"1036","article-title":"Pharmaceutical strategies for the topical dermal delivery of peptides \/ proteins for cosmetic and therapeutic applications","volume":"2","author":"Badenhorst T","year":"2016","journal-title":"Aust J Pharmacol Ther"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10611860903105986"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.12.014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2007.tb00443.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-12-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S106530"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03419.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1339-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00307.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2006.10.034"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182a806f0"},{"issue":"1","key":"e_1_2_7_24_1","first-page":"e527","article-title":"Effect of insulin on healing of pressure sore","volume":"1","author":"Ebrahimifard F","year":"2015","journal-title":"Arch Crit Care Med"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-7-S1-A259"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2012.00792.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.8.1082"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25300"}],"container-title":["Journal of Investigative and Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jicd.12437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jicd.12437","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jicd.12437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T21:06:26Z","timestamp":1693947986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jicd.12437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,27]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/jicd.12437"],"URL":"https:\/\/doi.org\/10.1111\/jicd.12437","archive":["Portico"],"relation":{},"ISSN":["2041-1618","2041-1626"],"issn-type":[{"value":"2041-1618","type":"print"},{"value":"2041-1626","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,27]]},"assertion":[{"value":"2018-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12437"}}