{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:24:24Z","timestamp":1768281864100,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To quantify the levels of miRNA\u2010146a in subgingival plaque samples, and correlate with periodontal and cardiac parameters, in chronic periodontitis patients with and without coronary heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study involved 90 subjects; 30\u00a0patients with chronic periodontitis and coronary heart disease (CP\u00a0+\u00a0CHD)\u00a0as part of Group I; group II comprising 30 with chronic periodontitis alone (CP); and group III comprising 30 systemically healthy controls. Demographic variables, periodontal parameters such as plaque index, bleeding on probing, probing pocket depth and clinical attachment levels, cardiac parameters such as total cholesterol, high\u2010density lipoprotein, low\u2010density lipoprotein, triglyceride levels, and systolic and diastolic blood pressure were recorded from the patients. miRNA\u2010146a level was analyzed in subgingival plaque samples by real\u2010time polymerase chain reaction assay and correlated with periodontal and cardiac parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>miRNA\u2010146a showed the highest levels in the CP\u00a0+\u00a0CHD group and also showed a positive correlation with body mass index, and periodontal and cardiac parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>miRNA\u2010146a is involved in the pathogenesis of both periodontitis and coronary heart disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12442","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T06:18:30Z","timestamp":1563949110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Periodontal\u2010Cardiovascular alliance: Evaluation of miRNA\u2010146a in subgingival plaque samples of chronic periodontitis patients with and without coronary heart disease"],"prefix":"10.1111","volume":"10","author":[{"given":"Krutika","family":"Yagnik","sequence":"first","affiliation":[{"name":"Department of Periodontics, Faculty of Dentistry Meenakshi Academy of Higher Education and Research Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4726-3727","authenticated-orcid":false,"given":"Jaideep","family":"Mahendra","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Faculty of Dentistry Meenakshi Academy of Higher Education and Research Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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