{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:34:00Z","timestamp":1776782040815,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to investigate the expression of Ki67, CD105 and \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA) expression in oral submucous fibrosis (OSF) and oral squamous cell carcinoma in the background of OSF (OSCC\u2010SMF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was carried out on paraffin\u2010embedded tissues of 30 normal oral mucosa (NOM), 50 OSF cases and 105 OSCC\u2010SMF. The immunohistochemistry was carried out to evaluate the expression of Ki67, CD105 and \u03b1\u2010SMA antigen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ki67 labelling index (LI), CD105 and \u03b1\u2010SMA expression showed increasing trend from NOM, low\u2010risk epithelial dysplasia (LRED), high\u2010risk epithelial dysplasia (HRED), well\u2010differentiated squamous cell carcinoma (WDSCC), moderately differentiated squamous cell carcinoma to poorly differentiated squamous cell carcinoma. However, there was no significant difference of \u03b1\u2010SMA expression between HRED and WDSCC. In OSCC\u2010SMF, Ki67 LI, CD105 and \u03b1\u2010SMA were significantly higher in advanced clinical TNM stage, metastasis and less than 3\u00a0years patient survival as compared with early clinical TNM stage, non\u2010metastasis and 3\u00a0years or more patient survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ki67 LI, \u03b1\u2010SMA and CD105 expression alone or together correspond with the disease progression model of SMF. Hence, expression of these markers can be used as a predictive marker of clinical outcome of OSCC\u2010SMF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12443","type":"journal-article","created":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T02:35:38Z","timestamp":1563590138000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Ki67, CD105 and \u03b1\u2010smooth muscle actin expression in disease progression model of oral submucous fibrosis"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-7694","authenticated-orcid":false,"given":"Amol R.","family":"Gadbail","sequence":"first","affiliation":[{"name":"Department of Dentistry Indira Gandhi Government Medical College and Hospital Nagpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minal S.","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences Sawangi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1856-0957","authenticated-orcid":false,"given":"Sachin C.","family":"Sarode","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Dr. D. 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Patil Dental College and Hospital Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0704-7509","authenticated-orcid":false,"given":"Shailesh M.","family":"Gondivkar","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology Government Dental College and Hospital Nagpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalita","family":"Belekar","sequence":"additional","affiliation":[{"name":"Department of Dentistry Indira Gandhi Government Medical College and Hospital Nagpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mugdha P.","family":"Mankar\u2010Gadbail","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Government Dental College and Hospital Nagpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Dande","sequence":"additional","affiliation":[{"name":"Department of Dentistry Indira 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