{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:28:36Z","timestamp":1785446916805,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lichen planus is a common chronic, inflammatory, immune\u2010mediated mucocutaneous disorder affecting the skin and mucosa. The role of mast cells in the genesis of lichen planus has been debated. Establishing a definitive part played by mast cells and its degranulation would possibly provide a permanent, cost\u2010effective treatment modality for oral lichen planus (OLP). This review aims to study the expression of mast cells qualitatively and quantitatively in OLP. The research questions were framed to assess the mast cell count, localization within the epithelium basement membrane zone and degranulation of mast cells. We performed a systematic search of PubMed, Medline, Cochrane and Web of Science. We found a total of 120 studies from which 12 were found suitable for the review. There is a marked increase in the number of mast cells in OLP. The mast cells were seen in increased numbers in the epithelial and connective tissue junction at areas of basement membrane disruption. There was also an increase in the degranulation of mast cells. It is evident that there is an increase in the mast cell number in lichen planus and its subsequent degranulation.<\/jats:p>","DOI":"10.1111\/jicd.12457","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T14:56:34Z","timestamp":1566917794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Mast cell expression in oral lichen planus: A systematic review"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1959-3419","authenticated-orcid":false,"given":"Jayanth Kumar","family":"Vadivel","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera","family":"Govindarajan","sequence":"additional","affiliation":[{"name":"R&amp;D Histopath Labs Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elangovan","family":"Somasundaram","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology KSR Institute of Dental Sciences and Research Tiruchengode India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Muthukrishnan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.06.077"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00946.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300405"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.49.89"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400304"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1976.tb01436.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1983.tb01101.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1995.tb01180.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4049\/jimmunol.156.1.275","article-title":"Mast cell tryptase is a mitogen for epithelial cells. 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