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Little is known about the genetic and cellular mechanism of plants' responses to Ca<jats:sup>2+<\/jats:sup> depletion. In this study, transcriptional profiling analysis helped identify multiple extracellular Ca<jats:sup>2+<\/jats:sup> ([Ca<jats:sup>2+<\/jats:sup>]<jats:sub>ext<\/jats:sub>) depletion\u2010responsive genes in <jats:italic>Arabidopsis thaliana<\/jats:italic> L., many of which are involved in response to other environmental stresses. Interestingly, a group of genes encoding putative cytosolic Ca<jats:sup>2+<\/jats:sup> ([Ca<jats:sup>2+<\/jats:sup>]<jats:sub>cyt<\/jats:sub>) sensors were significantly upregulated, implying that [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>cyt<\/jats:sub> has a role in sensing [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>ext<\/jats:sub> depletion. Consistent with this observation, [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>ext<\/jats:sub> depletion stimulated a transient rise in [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>cyt<\/jats:sub> that was negatively influenced by [K<jats:sup>+<\/jats:sup>]<jats:sub>ext<\/jats:sub>, suggesting the involvement of a membrane potential\u2010sensitive component. The [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>cyt<\/jats:sub> response to [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>ext<\/jats:sub> depletion was significantly desensitized after the initial treatment, which is typical of a receptor\u2010mediated signaling event. The response was insensitive to an animal Ca<jats:sup>2+<\/jats:sup> sensor antagonist, but was suppressed by neomycin, an inhibitor of phospholipase C. Gd<jats:sup>3+<\/jats:sup>, an inhibitor of Ca<jats:sup>2+<\/jats:sup> channels, suppressed the [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>ext<\/jats:sub>\u2010triggered rise in [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>cyt<\/jats:sub> and downstream changes in gene expression. Taken together, this study demonstrates that [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>cyt<\/jats:sub> plays an important role in the putative receptor\u2010mediated cellular and transcriptional response to [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>ext<\/jats:sub> depletion of plant cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jipb.12218","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T17:08:56Z","timestamp":1400692136000},"page":"138-150","source":"Crossref","is-referenced-by-count":13,"title":["Arabidopsis transcriptional response to extracellular Ca<sup>2+<\/sup> depletion involves a transient rise in cytosolic Ca<sup>2+<\/sup>"],"prefix":"10.1111","volume":"57","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"College of Life Sciences Inner Mongolia University Hohhot 010021 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