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We previously demonstrated that two light signaling factors, FAR\u2010RED ELONGATED HYPOCOTYL 3 (FHY3) and FAR\u2010RED IMPAIRED RESPONSE 1 (FAR1), regulate chlorophyll biosynthesis and seedling growth via controlling <jats:italic>HEMB1<\/jats:italic> expression in <jats:italic>Arabidopsis thaliana<\/jats:italic>. In this study, we reveal that FHY3 and FAR1 are involved in modulating plant immunity. We showed that the <jats:italic>fhy3 far1<\/jats:italic> double null mutant displayed high levels of reactive oxygen species and salicylic acid (SA) and increased resistance to <jats:italic>Pseudomonas syringae<\/jats:italic> pathogen infection. Microarray analysis revealed that a large proportion of pathogen\u2010related genes, particularly genes encoding nucleotide\u2010binding and leucine\u2010rich repeat domain resistant proteins, are highly induced in <jats:italic>fhy3 far1<\/jats:italic>. Genetic studies indicated that the defects of <jats:italic>fhy3 far1<\/jats:italic> can be largely rescued by reducing SA signaling or blocking SA accumulation, and by overexpression of <jats:italic>HEMB1<\/jats:italic>, which encodes a 5\u2010aminolevulinic acid dehydratase in the chlorophyll biosynthetic pathway. Furthermore, we found that transgenic plants with reduced expression of <jats:italic>HEMB1<\/jats:italic> exhibit a phenotype similar to <jats:italic>fhy3 far1<\/jats:italic>. Taken together, this study demonstrates an important role of FHY3 and FAR1 in regulating plant immunity, through integrating chlorophyll biosynthesis and the SA signaling pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jipb.12369","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T13:37:20Z","timestamp":1431956240000},"page":"91-103","source":"Crossref","is-referenced-by-count":73,"title":["A pair of light signaling factors FHY3 and FAR1 regulates plant immunity by modulating chlorophyll biosynthesis"],"prefix":"10.1111","volume":"58","author":[{"given":"Wanqing","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Photobiology Institute of Botany the Chinese Academy of Sciences Beijing 100093 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijiang","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photobiology Institute of Botany the Chinese Academy of Sciences Beijing 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