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Here, we report that OsINO80, a conserved ATP\u2010dependent chromatin\u2010remodeling factor in rice (<jats:italic>Oryza sativa<\/jats:italic>), functions in both GA biosynthesis and diverse biological processes. <jats:italic>OsINO80<\/jats:italic>\u2010knockdown mutants, derived from either T\u2010DNA insertion or RNA interference, display typical GA\u2010deficient phenotypes, including dwarfism, reduced cell length, late flowering, retarded seed germination and impaired reproductive development. Consistently, transcriptome analyses reveal that <jats:italic>OsINO80<\/jats:italic> knockdown results in downregulation by more than two\u2010fold of over 1,000 genes, including the GA biosynthesis genes <jats:italic>CPS1<\/jats:italic> and <jats:italic>GA3ox2<\/jats:italic>, and the dwarf phenotype of <jats:italic>OsINO80<\/jats:italic>\u2010knockdown mutants can be rescued by the application of exogenous GA3. Chromatin immunoprecipitation (ChIP) experiments show that OsINO80 directly binds to the chromatin of <jats:italic>CPS1<\/jats:italic> and <jats:italic>GA3ox2<\/jats:italic> loci. Biochemical assays establish that OsINO80 specially interacts with histone variant H2A.Z and the H2A.Z enrichments at <jats:italic>CPS1<\/jats:italic> and <jats:italic>GA3ox2<\/jats:italic> are decreased in <jats:italic>OsINO80<\/jats:italic>\u2010knockdown mutants. Thus, our study identified a rice chromatin\u2010remodeling factor, OsINO80, and demonstrated that OsINO80 is involved in regulation of the GA biosynthesis pathway and plays critical functions for many aspects of rice plant growth and development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jipb.12603","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T12:53:10Z","timestamp":1508244790000},"page":"144-159","source":"Crossref","is-referenced-by-count":48,"title":["Chromatin\u2010remodeling factor OsINO80 is involved in regulation of gibberellin biosynthesis and is crucial for rice plant growth and development"],"prefix":"10.1111","volume":"60","author":[{"given":"Chao","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and Development Institute of Plant Biology School of Life Sciences Fudan University Shanghai 200433 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