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As a signaling molecule, H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> plays important roles in plant growth and development, as well as environmental stress response. In <jats:italic>Arabidopsis<\/jats:italic>, there are three catalase genes, <jats:italic>CAT1<\/jats:italic>, <jats:italic>CAT2<\/jats:italic>, and <jats:italic>CAT3<\/jats:italic>. The encoded catalases are predominately peroxisomal proteins and are critical for scavenging H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. Since <jats:italic>CAT1<\/jats:italic> and <jats:italic>CAT3<\/jats:italic> are linked on chromosome 1, it has been almost impossible to generate <jats:italic>cat1\/3<\/jats:italic> and <jats:italic>cat1\/2\/3<\/jats:italic> mutants by traditional genetic tools. In this study, we constructed <jats:italic>cat1\/3<\/jats:italic> double mutants and <jats:italic>cat1\/2\/3<\/jats:italic> triple mutants by CRISPR\/Cas9 to investigate the role of catalases. The <jats:italic>cat1\/2\/3<\/jats:italic> triple mutants displayed severe redox disturbance and growth defects under physiological conditions compared with wild\u2010type and the <jats:italic>cat2\/3<\/jats:italic> double mutants. Transcriptome analysis showed a more profound transcriptional response in the <jats:italic>cat1\/2\/3<\/jats:italic> triple mutants compared to the <jats:italic>cat2\/3<\/jats:italic> mutants. These differentially expressed genes are involved in plant growth regulation as well as abiotic and biotic stress responses. In addition, expression of <jats:italic>OXI1<\/jats:italic> (<jats:italic>OXIDATIVE SIGNAL INDUCIBLE 1<\/jats:italic>) and several MAPK cascade genes were changed dramatically in the catalase triple mutant, suggesting that H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> produced in peroxisomes could serve as a peroxisomal retrograde signal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jipb.12649","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T15:16:20Z","timestamp":1521990980000},"page":"591-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["The <i>Arabidopsis<\/i> catalase triple mutant reveals important roles of catalases and peroxisome\u2010derived signaling in plant development"],"prefix":"10.1111","volume":"60","author":[{"given":"Tong","family":"Su","sequence":"first","affiliation":[{"name":"Shandong Provincial Key Laboratory of Plant Stress College of Life Sciences 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