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After uptake from the soil, iron is chelated by ligands and translocated from roots to shoots for subsequent utilization. However, the number of ligands involved in iron chelation is unclear. In this study, we identified and demonstrated that GLU1, which encodes a ferredoxin\u2010dependent glutamate synthase, was involved in iron homeostasis. First, the expression of <jats:italic>GLU1<\/jats:italic> was strongly induced by iron deficiency condition. Second, lesion of <jats:italic>GLU1<\/jats:italic> results in reduced transcription of many iron\u2010deficiency\u2010responsive genes in roots and shoots. The mutant plants revealed a decreased iron concentration in the shoots, and displayed severe leaf chlorosis under the condition of Fe limitation, compared to wild\u2010type. Third, the product of GLU1, glutamate, could chelate iron <jats:italic>in vivo<\/jats:italic> and promote iron transportation. Last, we also found that supplementation of glutamate in the medium can alleviate cadmium toxicity in plants. Overall, our results provide evidence that GLU1 is involved in iron homeostasis through affecting glutamate synthesis under iron deficiency conditions in <jats:italic>Arabidopsis<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/jipb.12985","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T14:40:11Z","timestamp":1593096011000},"page":"1925-1941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Glutamate synthase 1 is involved in iron\u2010deficiency response and long\u2010distance transportation in <i>Arabidopsis<\/i>"],"prefix":"10.1111","volume":"62","author":[{"given":"Man","family":"Cui","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design Chinese Academy of Sciences Beijing 100101 China"},{"name":"College of Advanced Agricultural Sciences 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