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This study investigates the role of resveratrol (Res), a stilbenoid with antioxidant properties, in protecting plants from high light damage. We found that exposure to high light increased reactive oxygen species (ROS) accumulation and induced photoinhibition in grapevine leaves. In response, Res biosynthesis was upregulated, along with an increase in stilbene synthase (<jats:italic>VvSTS<\/jats:italic>) expression. Application of exogenous Res alleviated ROS accumulation and improved photosynthetic efficiency. Further analysis revealed that the VvHY5\u2010VvBEE1 regulatory module plays a pivotal role in regulating <jats:italic>VvSTS<\/jats:italic> expression under high light conditions. Specifically, VvHY5 activated <jats:italic>VvSTS<\/jats:italic> expression, while VvBEE1 repressed it. Transgenic analysis showed that overexpression of <jats:italic>VvHY5<\/jats:italic> enhanced Res production and photoprotection, whereas overexpression of <jats:italic>VvBEE1<\/jats:italic> reduced Res levels and exacerbated light\u2010induced damage. VvHY5 and VvBEE1 competed for binding to the <jats:italic>VvSTS<\/jats:italic> promoter, with brassinosteroids (BRs) modulating their interaction. Our findings reveal the interplay between light signaling and brassinosteroid pathways in regulating Res biosynthesis, providing insights for protecting grapevines from sunburn.<\/jats:p>","DOI":"10.1111\/jipb.13895","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T21:36:21Z","timestamp":1743370581000},"page":"993-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["VvHY5 and VvBEE1 antagonistically control resveratrol biosynthesis to mitigate high light\u2010induced damage in grapevine"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0680-6528","authenticated-orcid":false,"given":"Zain","family":"Ali","sequence":"first","affiliation":[{"name":"College of Horticulture China Agricultural University Beijing 100193 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