{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:57:43Z","timestamp":1790859463238,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIPB"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Crocins, the main active ingredients in\n                    <jats:italic>Crocus sativus<\/jats:italic>\n                    , have anti\u2010inflammatory, antioxidant, hypolipidemic, hypoglycemic, and antitumor properties. Due to the harsh growing conditions and the limited yield of\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>sativus<\/jats:italic>\n                    , sustainable alternative methods for crocin production need to be explored. In this study, a new rice germplasm resource, \u201ccrocin rice\u201d, was developed by expressing eight genes of the crocin synthesis pathway in rice endosperm. The content of crocins in rice seeds was up to 9.25\u2009\u03bcg\/g dry weight, and it was also rich in a variety of carotenoids, including \u03b1\u2010carotene, lutein, and violaxanthin. The expression of exogenous genes did not affect normal growth or the major nutritional structure of rice. Feeding experiments on mice showed that crocin rice could effectively reduce lipopolysaccharide\u2010induced liver injury. With the adjuvant therapeutic benefits, crocin rice could be used to improve human nutrition and health. In addition, rice callus also showed the ability to synthesize crocins, which could serve as a potential substitute for\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>sativus<\/jats:italic>\n                    to alleviate resource shortage.\n                  <\/jats:p>","DOI":"10.1111\/jipb.70246","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:14:38Z","timestamp":1775038478000},"page":"3765-3775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic engineering of rice endosperm for crocin biosynthesis"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-2427","authenticated-orcid":false,"given":"Lijuan","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-8318","authenticated-orcid":false,"given":"Jianjie","family":"Gao","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5034-9823","authenticated-orcid":false,"given":"Wenhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6206-3272","authenticated-orcid":false,"given":"Yongdong","family":"Deng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5853-2029","authenticated-orcid":false,"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9905-7001","authenticated-orcid":false,"given":"Rihe","family":"Peng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5896-4334","authenticated-orcid":false,"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4616-9111","authenticated-orcid":false,"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1307-2199","authenticated-orcid":false,"given":"Hongjuan","family":"Han","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1794-2523","authenticated-orcid":false,"given":"Zhenjun","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3151-0778","authenticated-orcid":false,"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8507-0466","authenticated-orcid":false,"given":"Cen","family":"Qian","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1987-6112","authenticated-orcid":false,"given":"Yongsheng","family":"Tian","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1191-3513","authenticated-orcid":false,"given":"Quanhong","family":"Yao","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research, Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China"},{"name":"Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Official methods of analysis of the Association of Official Analytical Chemists","author":"A.O.A.C","year":"2005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11240-021-02028-z"},{"key":"e_1_2_9_4_1","first-page":"655","article-title":"Manual hematoxylin and eosin staining of mouse tissue sections","volume":"6","author":"Cardiff R.D.","year":"2014","journal-title":"Cold Spring Harb. Protoc."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-017-0665-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2015.094"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2019.158597"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009687511633"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12298-021-00938-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6020466"},{"key":"e_1_2_9_11_1","first-page":"3775","article-title":"Crocetin protects against fulminant hepatic failure induced by lipopolysaccharide\/D\u2010galactosamine by decreasing apoptosis, inflammation and oxidative stress in a rat model","volume":"18","author":"Gao K.","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2023.116283"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1045979"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.08.245"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2023.108195"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2018.11.012"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7652.2010.00543.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1150255"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11061074"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001250"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2011.04.012"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22456"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12374-021-09317-2"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201800516"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.13387"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.111.092254"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2011.197"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-023-02287-9"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2024.109051"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2020.10.019"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2004405117"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2125070"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2018.1492772"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.11.005"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.03.003"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-017-9534-0"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00266188"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2014.09.005"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-006-0583-3"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.13972"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jipb.13076"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2021.104969"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43897-022-00023-2"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.13059"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.13615"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00048194"},{"key":"e_1_2_9_48_1","first-page":"825","article-title":"Use of detergents in the analysis of fibrous feeds. \u2160. Preparation of fiber residues of low nitrogen content","volume":"46","author":"Van Soest P.J.","year":"1963","journal-title":"J. Assoc. Off. Agric. Chem."},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0024-z"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241814139"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gnh094"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2020.158664"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.13901"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/md22010022"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2018.09.007"}],"container-title":["Journal of Integrative Plant Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jipb.70246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jipb.70246","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jipb.70246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:15:27Z","timestamp":1790856927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jipb.70246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/jipb.70246"],"URL":"https:\/\/doi.org\/10.1111\/jipb.70246","archive":["Portico"],"relation":{},"ISSN":["1672-9072","1744-7909"],"issn-type":[{"value":"1672-9072","type":"print"},{"value":"1744-7909","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"2025-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}