{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:11:46Z","timestamp":1788613906193,"version":"build-2803163510"},"reference-count":75,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIPB"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Stomata are pores at the leaf surface that facilitate CO\n                    <jats:sub>2<\/jats:sub>\n                    entry for photosynthesis while controlling transpirational water loss. Stomatal movements are governed by reversible changes in turgor and cell volume, driven by the transport of osmotic solute across the membrane of guard cells surrounding the pore. Membrane transport depends on the activities of transporters and ion channels present at the membrane and also on their abundance, determined by vesicle traffic. Although much is known about how pumps and ion channels in the membrane are regulated, this is not the case for vesicle trafficking and certainly not in relation to CO\n                    <jats:sub>2<\/jats:sub>\n                    . Here, we report on experiments following the traffic of the K\n                    <jats:sup>+<\/jats:sup>\n                    channel KAT1 that is important for K\n                    <jats:sup>+<\/jats:sup>\n                    uptake during stomatal opening. We found that elevated CO\n                    <jats:sub>2<\/jats:sub>\n                    triggers changes in channel mobility within the plane of the plasma membrane and its internalization therefrom. CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010sensitive KAT1 traffic depends on SYP121, a vesicle\u2010trafficking (SNARE) protein previously associated with water stress and abscisic acid (ABA) that also binds the K\n                    <jats:sup>+<\/jats:sup>\n                    channel to promote its activation. The CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010sensitive pathway parallels vesicle traffic evoked by ABA, but it also shows important differences, with KAT1\u2013SYP121 binding sensitive to CO\n                    <jats:sub>2<\/jats:sub>\n                    . We show that stomatal response to changes in CO\n                    <jats:sub>2<\/jats:sub>\n                    levels is slowed in the\n                    <jats:italic>syp121<\/jats:italic>\n                    null mutant, affecting shoot growth and whole\u2010plant water\u2010use efficiency. Thus, we uncover a new target for CO\n                    <jats:sub>2<\/jats:sub>\n                    regulation in vesicle traffic and a novel perspective on plant responses to climate change.\n                  <\/jats:p>","DOI":"10.1111\/jipb.70269","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:58:11Z","timestamp":1776920291000},"page":"3391-3408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["CO\n                    <sub>2<\/sub>\n                    \u2010sensitive K\n                    <sup>+<\/sup>\n                    channel traffic affects stomata and whole\u2010plant water use"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0900-3043","authenticated-orcid":false,"given":"Zhiyi","family":"Yu","sequence":"first","affiliation":[{"name":"The School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences University of Glasgow Glasgow G12 8QQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1918-0673","authenticated-orcid":false,"given":"Sakharam","family":"Waghmare","sequence":"additional","affiliation":[{"name":"The School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences University of Glasgow Glasgow G12 8QQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5774-6466","authenticated-orcid":false,"given":"Sahar","family":"Farami","sequence":"additional","affiliation":[{"name":"The School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences University of Glasgow Glasgow G12 8QQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1361-4645","authenticated-orcid":false,"given":"Michael R.","family":"Blatt","sequence":"additional","affiliation":[{"name":"The School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences University of Glasgow Glasgow G12 8QQ UK"},{"name":"Laboratory of Plant Physiology and Biophysics University of Glasgow Glasgow G12 8QQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6876-4099","authenticated-orcid":false,"given":"Rucha","family":"Karnik","sequence":"additional","affiliation":[{"name":"The School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences University of Glasgow Glasgow G12 8QQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02248-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2016.07.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/plphys\/kiac149"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.16649"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.108.121129"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.16.1.221"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/plphys\/kiad630"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2021.08.010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004250050176"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.17.00078"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313x.1998.00343.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02076"},{"key":"e_1_2_9_15_1","first-page":"471","article-title":"Stomatal function in relation to leaf metabolism and environment","volume":"31","author":"Cowan I.R.","year":"1977","journal-title":"Symp. Soc. Exp. Biol."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2016.09.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2011.04786.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.12471"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3040.2007.01651.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.54.5.769"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/plphys\/kiab330"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.010328"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2144\/000113941"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.110.077768"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2010.04322.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nplants.2015.108"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2012.12.003"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.114.127159"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.15.00533"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.109.066118"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0733970100"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2009"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.68.1.863"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.16.01949"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.20.082503.103057"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1360-1385(02)02251-3"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.112.108506"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2016.10.006"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.114.134429"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8137.2008.02685.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.114.237107"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709732105"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.13392"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313x.2000.00886.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5401.537"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4811-5-6"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.19.00224"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1137\/0111030"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.092734"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3040.1990.tb01087.x"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.2.371"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06720"},{"key":"e_1_2_9_54_1","unstructured":"Office H.2017. UK Climate Change Risk Assessment 2017. DEFRA Policy paper. GOV.UK: HM Government."},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw0046"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48234-z"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.112.211938"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.17079"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1247\/csf.21.407"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.105.038950"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.07.020"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2007.03206.x"},{"key":"e_1_2_9_63_1","volume-title":"United Nations Framework Convention on Climate Change","author":"UNFCCC\u2010COP25","year":"2019"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06608"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.19.00919"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/plphys\/kiae541"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-70596-9"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.19.00266"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.18.00499"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.15.01050"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.18.01315"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.15.00305"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.10.015"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1807624115"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57287-7"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52338-x"}],"container-title":["Journal of Integrative Plant Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jipb.70269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jipb.70269","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jipb.70269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T12:15:38Z","timestamp":1788610538000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jipb.70269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":75,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jipb.70269"],"URL":"https:\/\/doi.org\/10.1111\/jipb.70269","archive":["Portico"],"relation":{},"ISSN":["1672-9072","1744-7909"],"issn-type":[{"value":"1672-9072","type":"print"},{"value":"1744-7909","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]},"assertion":[{"value":"2025-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}