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In this study, we describe the isolation and characterization of the\n                    <jats:italic>more adventitious roots1\u20101<\/jats:italic>\n                    (\n                    <jats:italic>mars1\u20101<\/jats:italic>\n                    ) mutant, which exhibits enhanced regenerative potential upon wounding in tomato hypocotyl explants. Additionally, the\n                    <jats:italic>mars1\u20101<\/jats:italic>\n                    fruits exhibited a rough surface because of ectopic subepidermal cell proliferation, resulting in the formation of callus\u2010like structures on their cuticle. The\n                    <jats:italic>MARS1\/ROUGH<\/jats:italic>\n                    gene encodes a conserved lysine\u2010specific histone demethylase, SlLDL1, which regulates processes such as cell proliferation, stem cell pluripotency, and embryogenesis in metazoans. Two CRISPR\/Cas9 null alleles,\n                    <jats:italic>mars1\u20102<\/jats:italic>\n                    and\n                    <jats:italic>mars1\u20103<\/jats:italic>\n                    , were generated, and their pleiotropic phenotypes were characterized. ChIP\u2010seq analysis revealed elevated levels of methylated lysine 4 in histone 3 within specific regions of the\n                    <jats:italic>mars1\/rough<\/jats:italic>\n                    genome. To determine the impact of altered epigenetic marks on gene expression regulation in\n                    <jats:italic>mars1\/rough<\/jats:italic>\n                    mutants, we analyzed the transcriptome of tomato hypocotyls during adventitious root formation. Using specific bioinformatic workflows and the resolution of the directional RNA\u2010seq data, we identified several dozen distinct genomic regions with\n                    <jats:italic>de novo<\/jats:italic>\n                    expression in the\n                    <jats:italic>mars1\/rough<\/jats:italic>\n                    mutants. One such region includes a novel B\u2010type cyclin gene that is upregulated in\n                    <jats:italic>mars1\/rough<\/jats:italic>\n                    mutants and may account for adventitious root and fruit skin phenotypes. Our findings indicate that SlLDL1 plays a role in maintaining silencing in specific genomic regions that are essential for tissue\u2010specific reprogramming.\n                  <\/jats:p>","DOI":"10.1111\/jipb.70287","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:09:33Z","timestamp":1778846973000},"page":"3644-3669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of the tomato\n                    <i>MARS1\/ROUGH<\/i>\n                    gene encoding a LYSINE\u2010SPECIFIC HISTONE DEMETHYLASE 1 in adventitious root and fruit skin formation"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8838-4974","authenticated-orcid":false,"given":"Eduardo","family":"Larriba","sequence":"first","affiliation":[{"name":"Instituto de Bioingenier\u00eda Universidad Miguel Hern\u00e1ndez Elche 03202 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