{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:54:19Z","timestamp":1781520859955,"version":"3.54.1"},"reference-count":76,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIPB"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Vitamin B6 (VB6) is an essential nutrient that must be obtained from the diet by humans and livestock, and plays an important role in response to various biotic and abiotic stresses in plants. Although the VB6 biosynthesis pathway has been uncovered in higher plants, understanding of its genetic control remains limited, and the role of VB6 in responding to cold stress is largely unknown. Here, we showed that variation in VB6 levels in rice is attributable to differential transcription of\n                    <jats:italic>OsPDX1.2<\/jats:italic>\n                    , a pyridoxal phosphate synthase, due to polymorphisms in its promoter. Natural variations in the\n                    <jats:italic>OsPDX1.2<\/jats:italic>\n                    promoter affect the binding affinity of OsbZIP18, a transcriptional factor repressing\n                    <jats:italic>OsPDX1.2<\/jats:italic>\n                    transcription. Loss of function in\n                    <jats:italic>OsPDX1.2<\/jats:italic>\n                    or overexpression of\n                    <jats:italic>OsbZIP18<\/jats:italic>\n                    significantly reduces cold tolerance in rice. Further investigation revealed that both genes affect cold tolerance by regulating VB6 and abscisic acid (ABA) biosynthesis. Moreover, the frequency of the cold\u2010tolerant\n                    <jats:italic>pOsPDX1.2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>Hap2<\/jats:italic>\n                    <\/jats:sup>\n                    increases at higher latitudes, whereas the cold\u2010sensitive\n                    <jats:italic>pOsPDX1.2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>Hap1<\/jats:italic>\n                    <\/jats:sup>\n                    increases at lower latitudes, indicating that natural variation in\n                    <jats:italic>OsPDX1.2<\/jats:italic>\n                    contributes to differential cold adaptation in rice. Overall, our results reveal a regulatory pathway controlling rice VB6 accumulation and cold tolerance via the OsbZIP18\u2013\n                    <jats:italic>OsPDX1.2<\/jats:italic>\n                    module, providing a potential target for improving rice quality and stress tolerance.\n                  <\/jats:p>","DOI":"10.1111\/jipb.70322","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:19:35Z","timestamp":1781518775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural variation in the promoter of\n                    <i>OsPDX1.2<\/i>\n                    enhances vitamin B6 accumulation and cold tolerance in rice"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0978-8191","authenticated-orcid":false,"given":"Bi","family":"Wang","sequence":"first","affiliation":[{"name":"National Salt\u2010Alkali Tolerant Rice Technology Innovation 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Multiplication) and College of Tropical Agriculture and Forestry Hainan University Sanya 572025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5308-9326","authenticated-orcid":false,"given":"Rong Hui","family":"Li","sequence":"additional","affiliation":[{"name":"National Salt\u2010Alkali Tolerant Rice Technology Innovation Center, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication) and College of Tropical Agriculture and Forestry Hainan University Sanya 572025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2050-7695","authenticated-orcid":false,"given":"Xu Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Salt\u2010Alkali Tolerant Rice Technology Innovation Center, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication) and College of Tropical Agriculture and Forestry Hainan University Sanya 572025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3750-0409","authenticated-orcid":false,"given":"Li Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"National Salt\u2010Alkali Tolerant Rice Technology Innovation Center, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication) and College of Tropical Agriculture and Forestry Hainan University Sanya 572025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1486-6691","authenticated-orcid":false,"given":"Shi Jia","family":"Xia","sequence":"additional","affiliation":[{"name":"National Salt\u2010Alkali Tolerant Rice Technology Innovation Center, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication) and College of Tropical Agriculture and Forestry Hainan University Sanya 572025 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