{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:09:30Z","timestamp":1784214570601,"version":"3.55.0"},"reference-count":71,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIPB"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Phytophthora infestans<\/jats:italic>\n                    , the causal agent of late blight in potato and tomato, is a historically devastating pathogen that continues to pose a major threat to global food security. Although conventional fungicides remain a cornerstone of crop protection, growing concerns over their environmental impact and long\u2010term sustainability have driven the search for safer and more selective alternatives. In this context, next\u2010generation fungicides with high specificity and minimal ecological footprint are urgently needed. This study introduces CP32, a small cyclic peptide, identified via yeast two\u2010hybrid screening of a genetically encoded combinatorial peptide library, based on its specific interaction with the catalytic domain of the\n                    <jats:italic>P. infestans<\/jats:italic>\n                    enzyme Cellulose Synthase 2. CP32 exhibits anti\u2010oomycete activity, effectively inhibits sporangial growth at low micromolar concentrations, and significantly reduces late blight symptoms on tomato leaves and entire plants.\n                    <jats:italic>In silico<\/jats:italic>\n                    docking analyses, supported by molecular and biochemical evidence, confirm that CP32 compromises cell\u2010wall integrity by interfering with cellulose deposition and altering glucan composition. Furthermore, CP32 readily permeates the\n                    <jats:italic>Phytophthora<\/jats:italic>\n                    membrane and displays oomycete\u2010static properties, while showing no detectable toxicity toward non\u2010target organisms, such as bacteria, yeast, or plants. Collectively, these findings identify CP32 as a promising, targeted anti\u2010oomycete agent with a unique mode of action, targeting the\n                    <jats:italic>P. infestans<\/jats:italic>\n                    cell wall, representing a valuable contribution to the development of sustainable strategies for the control of late blight.\n                  <\/jats:p>","DOI":"10.1111\/jipb.70343","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T14:46:01Z","timestamp":1784213161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CP32, a novel anti\u2010oomycete cyclic peptide, interferes with cell\u2010wall deposition in\n                    <i>Phytophthora infestans<\/i>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4781-9593","authenticated-orcid":false,"given":"Demetrio","family":"Marcian\u00f2","sequence":"first","affiliation":[{"name":"Dipartimento di Bioscienze, Universit\u00e0 degli Studi di Milano Milano 20133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0856-6351","authenticated-orcid":false,"given":"Stefano","family":"Rosa","sequence":"additional","affiliation":[{"name":"Dipartimento di Bioscienze, Universit\u00e0 degli Studi di Milano Milano 20133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-898X","authenticated-orcid":false,"given":"Elena","family":"Marone Fassolo","sequence":"additional","affiliation":[{"name":"Dipartimento di Bioscienze, Universit\u00e0 degli Studi di Milano Milano 20133 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