{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:10:07Z","timestamp":1788779407062,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIPB"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Drought stress severely constrains wheat (\n                    <jats:italic>Triticum aestivum<\/jats:italic>\n                    L.) growth and productivity. Here, we identify the histone deacetylase TaHDA1 as a negative regulator of drought tolerance in wheat. We demonstrate that TaHDA1 interacts with and deacetylates the L\u2010glutamate decarboxylase TaGAD1 at lysine 493, promoting its ubiquitination\u2010dependent degradation and thereby suppressing \u03b3\u2010aminobutyric acid (GABA) accumulation. Loss of TaHDA1 function enhances TaGAD1 stability, increases GABA levels, and confers markedly improved drought tolerance, along with elevated grain GABA content. Integrated multi\u2010omics analyses further reveal that TaHDA1 globally modulates H3K9 acetylation to orchestrate drought\u2010responsive transcriptional programs. Notably,\n                    <jats:italic>tahda1<\/jats:italic>\n                    \u2010ko mutants show a slight reduction in grain size under normal conditions, but maintain stable yield under drought stress. Our findings uncover a dual mechanism by which TaHDA1 integrates non\u2010histone and histone deacetylation to balance growth and stress adaptation, providing a promising target for breeding drought\u2010resilient and nutritionally enhanced wheat varieties.\n                  <\/jats:p>","DOI":"10.1111\/jipb.70384","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:21:23Z","timestamp":1788776483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TaHDA1\u2010mediated histone and non\u2010histone deacetylation orchestrates drought tolerance in wheat"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0846-0856","authenticated-orcid":false,"given":"Jinpeng","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of High\u2010Efficiency Production of Wheat\u2010Maize Double Cropping, College of Agronomy and Biotechnology China Agricultural University Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9015-9742","authenticated-orcid":false,"given":"Danyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High\u2010Efficiency Production of Wheat\u2010Maize Double Cropping, College of Agronomy and Biotechnology China Agricultural University Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6117-7357","authenticated-orcid":false,"given":"Xiao","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High\u2010Efficiency Production of Wheat\u2010Maize Double Cropping, College of Agronomy and Biotechnology China Agricultural University Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2494-0425","authenticated-orcid":false,"given":"Xinran","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High\u2010Efficiency Production of Wheat\u2010Maize Double Cropping, College of Agronomy and Biotechnology China Agricultural University Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6910-5697","authenticated-orcid":false,"given":"Chenji","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High\u2010Efficiency Production of Wheat\u2010Maize Double Cropping, College of Agronomy and Biotechnology China Agricultural University Beijing 100193 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