{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:12:21Z","timestamp":1789819941094,"version":"4.0.1"},"reference-count":63,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIPB"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cucurbitacin B (CuB), a key compound responsible for the bitterness of melon fruit, significantly reduces fruit quality and consumer acceptance. Therefore, understanding the molecular mechanism underlying CuB biosynthesis is essential for improving melon fruit quality. In this research, we investigated CuB levels in the\n                    <jats:italic>cmwrky13<\/jats:italic>\n                    \u2010knockout mutant following treatment with 20\u2009mg\u2009L\n                    <jats:sup>\u22121<\/jats:sup>\n                    CPPU (20CPPU) and hand pollination. The CuB content decreased by approximately 30% in the\n                    <jats:italic>cmwrky13<\/jats:italic>\n                    \u2010knockout mutant compared with wild type under 20CPPU treatment. Yeast one\u2010hybrid, dual\u2010luciferase, and electrophoretic mobility shift assays demonstrated that CmWRKY13 activates the promoter of\n                    <jats:italic>CmBr<\/jats:italic>\n                    , a key regulator of bitterness, and physically interacts with CmBr. Moreover, the nuclear\u2010localized transcription factor\n                    <jats:italic>CmMYB6<\/jats:italic>\n                    was specifically induced by 20CPPU treatment. Interestingly, CmMYB6 binds to the\n                    <jats:italic>CmWRKY13<\/jats:italic>\n                    promoter and interacts with its protein, synergistically enhancing CuB gene expression. The\n                    <jats:italic>cmmyb6<\/jats:italic>\n                    \u2010knockout mutants confirmed that CmMYB6 positively regulates CuB accumulation in melon fruit. Furthermore, CRISPR\/Cas9\u2010generated\n                    <jats:italic>cmmyb6 cmwrky13<\/jats:italic>\n                    double mutants revealed that the CmMYB6\u2013CmWRKY13 module controls\n                    <jats:italic>CmBr<\/jats:italic>\n                    expression and regulates CuB accumulation. Collectively, these findings elucidate the transcriptional cascade of CuB accumulation mediated by the CmMYB6\u2013CmWRKY13\u2013CmBr module in melon fruit, providing new insights into the molecular basis of bitterness formation and offering theoretical guidance for the breeding of non\u2010bitter melon varieties.\n                  <\/jats:p>","DOI":"10.1111\/jipb.70388","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:40:39Z","timestamp":1789818039000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The CmMYB6\u2013CmWRKY13\u2013CmBr module mediates cucurbitacin B accumulation in melon fruit under CPPU treatment"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8257-8003","authenticated-orcid":false,"given":"Fei","family":"Luo","sequence":"first","affiliation":[{"name":"College of Horticulture Shenyang Agricultural University Shenyang 110866 China"},{"name":"College of Horticulture Hebei Agricultural University Baoding 071001 China"},{"name":"Key Laboratory of Protected Horticulture (Shenyang Agricultural University), Ministry of Education Shenyang 110866 China"},{"name":"National &amp; Local Joint Engineering Research Center of Northern Horticultural Facilities Design &amp; Application Technology Shenyang 110866 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8261-032X","authenticated-orcid":false,"given":"Haoxiong","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Horticulture Shenyang Agricultural University Shenyang 110866 China"},{"name":"Key Laboratory of Protected Horticulture (Shenyang Agricultural University), Ministry of Education Shenyang 110866 China"},{"name":"National &amp; Local Joint Engineering Research Center of Northern Horticultural Facilities Design &amp; Application Technology Shenyang 110866 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4655-3792","authenticated-orcid":false,"given":"Yuqing","family":"Han","sequence":"additional","affiliation":[{"name":"College of Horticulture Shenyang Agricultural University Shenyang 110866 China"},{"name":"Key Laboratory of Protected Horticulture (Shenyang Agricultural University), Ministry of Education Shenyang 110866 China"},{"name":"National &amp; Local Joint Engineering Research Center of Northern Horticultural Facilities Design &amp; Application Technology Shenyang 110866 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8543-3565","authenticated-orcid":false,"given":"Liyuan","family":"Zhen","sequence":"additional","affiliation":[{"name":"College of Horticulture Shenyang Agricultural University Shenyang 110866 China"},{"name":"Key Laboratory of Protected Horticulture (Shenyang Agricultural University), Ministry of Education Shenyang 110866 China"},{"name":"National &amp; Local Joint Engineering Research Center of Northern Horticultural Facilities Design &amp; Application Technology Shenyang 110866 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4618-9699","authenticated-orcid":false,"given":"Ruirui","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Horticulture Shenyang Agricultural University Shenyang 110866 China"},{"name":"Key Laboratory of Protected Horticulture (Shenyang Agricultural University), Ministry of Education Shenyang 110866 China"},{"name":"National &amp; Local Joint Engineering Research Center of Northern Horticultural Facilities Design &amp; Application Technology Shenyang 110866 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9471-7463","authenticated-orcid":false,"given":"Yushan","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Horticulture Shenyang Agricultural University Shenyang 110866 China"},{"name":"Key Laboratory of Protected Horticulture (Shenyang Agricultural University), Ministry of Education Shenyang 110866 China"},{"name":"National &amp; Local Joint Engineering Research Center of Northern Horticultural Facilities Design &amp; Application Technology Shenyang 110866 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9764-9686","authenticated-orcid":false,"given":"Jian","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Horticulture Shenyang Agricultural University Shenyang 110866 China"},{"name":"Key Laboratory of Protected Horticulture (Shenyang Agricultural University), Ministry of Education Shenyang 110866 China"},{"name":"National &amp; Local Joint Engineering Research Center of Northern Horticultural Facilities Design &amp; Application Technology Shenyang 110866 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9917-7046","authenticated-orcid":false,"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Horticulture Shenyang Agricultural University Shenyang 110866 China"},{"name":"Key Laboratory of Protected Horticulture (Shenyang Agricultural University), Ministry of Education Shenyang 110866 China"},{"name":"National &amp; Local Joint Engineering Research Center of Northern Horticultural Facilities Design &amp; Application Technology Shenyang 110866 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9691-0508","authenticated-orcid":false,"given":"Hongyan","family":"Qi","sequence":"additional","affiliation":[{"name":"College of Horticulture Shenyang Agricultural University Shenyang 110866 China"},{"name":"Key Laboratory of Protected Horticulture (Shenyang Agricultural University), Ministry of Education Shenyang 110866 China"},{"name":"National &amp; Local Joint Engineering Research Center of Northern Horticultural Facilities Design &amp; Application Technology Shenyang 110866 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.scienta.2015.07.011","article-title":"CPPU treatment and pollination: Their combined effect on kiwifruit growth and quality","volume":"193","author":"Ainalidou A.","year":"2015","journal-title":"Sci. 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