{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:04:08Z","timestamp":1789563848359,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIPB"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Seed oil content, protein content, and yield are agronomically important, correlated traits that determine the economic value of soybean (\n                    <jats:italic>Glycine max<\/jats:italic>\n                    ). However, improving seed quality and yield simultaneously is challenging because gains in one breeding target often compromise the other, and the genetic basis of this trade\u2010off is poorly understood. Here, we performed a genome\u2010wide association study of 429 diverse soybean accessions and identified\n                    <jats:italic>Seed Oil and Protein 5<\/jats:italic>\n                    (\n                    <jats:italic>SOP5<\/jats:italic>\n                    ), which encodes a kinesin protein, as a key locus associated with seed oil and protein content. Knockout and overexpression experiments demonstrated that\n                    <jats:italic>GmSOP5<\/jats:italic>\n                    positively affects seed oil content and 100\u2010seed weight and negatively influences seed protein content.\n                    <jats:italic>GmSOP5<\/jats:italic>\n                    is located in a selective sweep region, and the domestication\u2010related\n                    <jats:italic>GmSOP5<\/jats:italic>\n                    <jats:sup>H1<\/jats:sup>\n                    allele is nearly fixed in cultivated soybean, contributing to increased seed size, weight, and oil content and reduced protein content. Field trials demonstrated that neither loss\u2010of\u2010function\n                    <jats:italic>GmSOP5<\/jats:italic>\n                    \u2010edited mutants, which have increased seed protein content, nor\n                    <jats:italic>GmSOP5<\/jats:italic>\n                    \u2010overexpression lines, which have increased seed oil content, differed significantly in yield from wild\u2010type plants, because changes in plant architecture were offset by changes in seed weight. Our results shed light on soybean domestication and suggest how pleiotropy can be harnessed in breeding to enhance seed quality without compromising yield.\n                  <\/jats:p>","DOI":"10.1111\/jipb.70392","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:13:59Z","timestamp":1789560839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural variation in\n                    <i>GmSOP5<\/i>\n                    regulates seed oil and protein content during soybean domestication"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-0156","authenticated-orcid":false,"given":"Yu","family":"Tian","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 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Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 China"},{"name":"National Nanfan Research Institute (Sanya) Chinese Academy of Agricultural Sciences Sanya 572024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0655-515X","authenticated-orcid":false,"given":"Long","family":"Yan","sequence":"additional","affiliation":[{"name":"Institute of Cereal and Oil Crops Hebei Academy of Agricultural and Forestry Sciences Hebei 050035 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-8796","authenticated-orcid":false,"given":"Chaosen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Oil Crops Biology Crops Research Institute of Jiangxi Nanchang 330200 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