{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:03:55Z","timestamp":1789563835704,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2022YFF1001603"],"award-info":[{"award-number":["2022YFF1001603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIPB"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Heat stress severely impairs plant growth and limits crop productivity. GSK3\u2010like family proteins regulate diverse cellular processes, including plant responses to abiotic and biotic stresses. Nevertheless, their specific functions in heat stress responses remain poorly characterized. Here, we demonstrate that the expression of\n                    <jats:italic>OsSK13<\/jats:italic>\n                    and the protein abundance of OsSK12\/13 increase under heat stress in rice. Mutation in both\n                    <jats:italic>OsSK12\/13<\/jats:italic>\n                    compromises thermotolerance at both vegetative and reproductive stages, whereas overexpression of\n                    <jats:italic>OsSK13<\/jats:italic>\n                    enhances seedling thermotolerance. We further identify that OsSK12\/13 physically interact with and phosphorylate the APETALA2\/ETHYLENE RESPONSIVE FACTOR (AP2\/ERF) transcription factor OsERF60, and phosphorylation by OsSK12\/13 enhances the stability of OsERF60. Consistent with its role in this regulatory module,\n                    <jats:italic>OsERF60<\/jats:italic>\n                    loss\u2010of\u2010function mutants exhibit enhanced thermosensitivity at vegetative and reproductive stages. Expression profiling reveals that induction of heat stress\u2010responsive genes, including\n                    <jats:italic>OsHsfA2c,<\/jats:italic>\n                    is reduced in both the\n                    <jats:italic>OsSK12\/13<\/jats:italic>\n                    double mutant and the\n                    <jats:italic>OsERF60<\/jats:italic>\n                    mutant. OsERF60 directly binds to the\n                    <jats:italic>OsHsfA2c<\/jats:italic>\n                    promoter and activates its expression. Collectively, our findings uncover the OsSK12\/13\u2010OsERF60\u2010OsHsfA2c regulatory module as a key component of the heat stress response in rice and provide mechanistic insights into thermotolerance in plants.\n                  <\/jats:p>","DOI":"10.1111\/jipb.70397","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:12:52Z","timestamp":1789560772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An OsSK12\/13\u2010OsERF60\u2010OsHsfA2c module regulates heat stress tolerance in rice"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4940-0672","authenticated-orcid":false,"given":"Juan","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience College of Life Sciences, Zhejiang University Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5259-585X","authenticated-orcid":false,"given":"Zi\u2010Wei","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience College of Life Sciences, Zhejiang University Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9663-3088","authenticated-orcid":false,"given":"Zhi\u2010Ping","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro\u2010Products Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3305-2494","authenticated-orcid":false,"given":"Jing\u2010Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience College of Life Sciences, Zhejiang University Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9696-5131","authenticated-orcid":false,"given":"Dong\u2010Jie","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience College of Life Sciences, Zhejiang University Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4047-432X","authenticated-orcid":false,"given":"Dai\u2010Xi","family":"Yue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience College of Life Sciences, Zhejiang University Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-9764","authenticated-orcid":false,"given":"Hai\u2010Ping","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience College of Life Sciences, Zhejiang University Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0791-1301","authenticated-orcid":false,"given":"Jian\u2010Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience College of Life Sciences, Zhejiang University Hangzhou 310027 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