{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:03:42Z","timestamp":1789974222241,"version":"4.0.1"},"reference-count":83,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005236","name":"Chinese Universities Scientific Fund","doi-asserted-by":"publisher","award":["2026TC023"],"award-info":[{"award-number":["2026TC023"]}],"id":[{"id":"10.13039\/501100005236","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32320103003"],"award-info":[{"award-number":["32320103003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIPB"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    Ethylene Response 1 (ETR1) has long been viewed as a canonical hormone receptor initiating ethylene signaling at the endoplasmic reticulum (ER). Recent studies demonstrate that ETR1 also acts as an ER redox sensor, with disulfide\u2010dependent dimerization controlling receptor conformation and activity. In parallel, subfamily I ethylene receptors, including ETR1, function as Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010permeable channels, directly linking ethylene perception to rapid cytosolic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    elevation. Here, we summarize emerging evidence that redefines ETR1 as a multifunctional signaling hub connecting ethylene perception, redox regulation, and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling. We present this integration as a working model and highlight unresolved questions concerning the mechanistic relationships among these functions. This framework provides a new perspective on how plants integrate ER homeostasis with hormone signaling to coordinate development and stress adaptation.\n                  <\/jats:p>","DOI":"10.1111\/jipb.70398","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:33:18Z","timestamp":1789972398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ethylene receptors at the ER: Potential hubs integrating hormone, redox, and Ca\n                    <sup>2+<\/sup>\n                    signaling"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5850-2930","authenticated-orcid":false,"given":"Qianshen","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience, College of Biological Sciences China Agricultural University Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-9505","authenticated-orcid":false,"given":"Yiping","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience, College of Biological Sciences China Agricultural University Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1153-8289","authenticated-orcid":false,"given":"Ruiqi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience, College of Biological Sciences China Agricultural University Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3650-7374","authenticated-orcid":false,"given":"Jiale","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience, College of Biological Sciences China Agricultural University Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-316X","authenticated-orcid":false,"given":"Savithramma P.","family":"Dinesh\u2010Kumar","sequence":"additional","affiliation":[{"name":"Department of Plant Biology and The Genome Center, College of Biological Sciences University of California Davis 95616 California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3850-3274","authenticated-orcid":false,"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Plant and Environmental Sciences Virginia Tech Virginia 24061 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6790-1044","authenticated-orcid":false,"given":"Yongliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience, College of Biological Sciences China Agricultural University Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1105\/tpc.110.076588","article-title":"Ethylene\u2010induced stabilization of ETHYLENE INSENSITIVE3 and EIN3\u2010LIKE1 is mediated by proteasomal degradation of EIN3 binding F\u2010box 1 and 2 that requires EIN2 in Arabidopsis","volume":"22","author":"An F.","year":"2010","journal-title":"Plant Cell"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1042\/BST20150233","article-title":"ER\u2010luminal thiol\/selenol\u2010mediated regulation of Ca2+ signalling","volume":"44","author":"Appenzeller\u2010Herzog C.","year":"2016","journal-title":"Biochem. 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