{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:15:44Z","timestamp":1790525744091,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>22q11 deletion syndrome (22q11<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>) is associated with mild or borderline intellectual disability (<jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>). There are hardly any reports on subjects with 22q11<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> with moderate or severe <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>, and therefore its behavioural and psychiatric characteristics are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We describe behavioural and psychiatric characteristics of 33 adults with 22q11<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> and a <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ull\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale <jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FSIQ<\/jats:styled-content>) below 55. Participants were divided into two groups: one group having a <jats:styled-content style=\"fixed-case\">FSIQ<\/jats:styled-content>\u2009\u2264\u200955 caused by intellectual decline (<jats:italic>n<\/jats:italic>\u2009=\u200921) and one group with a <jats:styled-content style=\"fixed-case\">FSIQ<\/jats:styled-content>\u2009\u2264\u200955 who had always functioned at this level (<jats:italic>n<\/jats:italic>\u2009=\u200912).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High scores on psychopathology sub\u2010scales were found for both subgroups. 22q11<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> patients with intellectual decline showed higher rates of co\u2010morbid psychopathology, particularly psychosis. Furthermore, psychosis and intellectual decline were positive correlated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first report addressing adult patients with 22q11<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> and moderate to severe <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>. Overall we found high levels of psychopathology with higher scores of psychopathology in the intellectual decline group. Life time psychosis seems to be related to deterioration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12117","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T11:54:29Z","timestamp":1392638069000},"page":"915-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Psychopathology in adults with 22q11 deletion syndrome and moderate and severe intellectual disability"],"prefix":"10.1111","volume":"58","author":[{"given":"L. J. M.","family":"Evers","sequence":"first","affiliation":[{"name":"MFCG Koraalgroup  Heel The Netherlands"},{"name":"Governor Kremers Centre Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. A. M. 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