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Although much research has focused on mathematics skills among individuals with <jats:styled-content style=\"fixed-case\">VCFS<\/jats:styled-content>, no studies have examined predictors of reading comprehension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>\u200369 late adolescents with <jats:styled-content style=\"fixed-case\">VCFS<\/jats:styled-content>, 23 siblings of youth with <jats:styled-content style=\"fixed-case\">VCFS<\/jats:styled-content> and 30 community controls participated in a longitudinal research project and had repeat neuropsychological test batteries and psychiatric evaluations every 3 years. The <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>echsler <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndividual <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>chievement <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>est \u2013 2nd edition (<jats:styled-content style=\"fixed-case\">WIAT\u2010II<\/jats:styled-content>) Reading Comprehension subtest served as our primary outcome variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u2003Consistent with previous research, children and adolescents with <jats:styled-content style=\"fixed-case\">VCFS<\/jats:styled-content> had mean reading comprehension scores on the <jats:styled-content style=\"fixed-case\">WIAT\u2010II<\/jats:styled-content>, that were approximately two standard deviations below the mean and word reading scores approximately one standard deviation below the mean. A more novel finding is that relative to both control groups, individuals with <jats:styled-content style=\"fixed-case\">VCFS<\/jats:styled-content> demonstrated a longitudinal <jats:italic>decline<\/jats:italic> in reading comprehension abilities yet a slight <jats:italic>increase<\/jats:italic> in word reading abilities. In the combined control sample, <jats:styled-content style=\"fixed-case\">WISC\u2010III FSIQ<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">WIAT\u2010II<\/jats:styled-content> Word Reading, <jats:styled-content style=\"fixed-case\">WISC\u2010III<\/jats:styled-content> Vocabulary and <jats:styled-content style=\"fixed-case\">CVLT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> List A Trial 1 accounted for 75% of the variance in Time 3 <jats:styled-content style=\"fixed-case\">WIAT\u2010II<\/jats:styled-content> Reading Comprehension scores. In the <jats:styled-content style=\"fixed-case\">VCFS<\/jats:styled-content> sample, <jats:styled-content style=\"fixed-case\">WISC\u2010III FSIQ<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">BASC<\/jats:styled-content>\u2010Teacher Aggression, <jats:styled-content style=\"fixed-case\">CVLT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> Intrusions, Tower of <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ondon, <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>isual <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>pan <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ackwards, <jats:styled-content style=\"fixed-case\">WCST<\/jats:styled-content> Non\u2010perseverative Errors, <jats:styled-content style=\"fixed-case\">WIAT\u2010II<\/jats:styled-content> Word Reading and <jats:styled-content style=\"fixed-case\">WISC\u2010III<\/jats:styled-content> Freedom from Distractibility index accounted for 85% of the variance in Time 3 <jats:styled-content style=\"fixed-case\">WIAT\u2010II<\/jats:styled-content> Reading Comprehension scores. A principal component analysis with promax rotation computed on the statistically significant Time 1 predictor variables in the <jats:styled-content style=\"fixed-case\">VCFS<\/jats:styled-content> sample resulted in three factors: Word reading decoding\/Interference control, Self\u2010Control\/Self\u2010Monitoring and Working Memory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\u2003Childhood predictors of late adolescent reading comprehension in <jats:styled-content style=\"fixed-case\">VCFS<\/jats:styled-content> differ in some meaningful ways from predictors in the non\u2010<jats:styled-content style=\"fixed-case\">VCFS<\/jats:styled-content> population. These results offer some guidance for how best to consider intervention efforts to improve reading comprehension in the <jats:styled-content style=\"fixed-case\">VCFS<\/jats:styled-content> population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12134","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T10:08:44Z","timestamp":1401098924000},"page":"926-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Predicting reading comprehension academic achievement in late adolescents with velo\u2010cardio\u2010facial (22q11.2 deletion) syndrome (<scp>VCFS<\/scp>): a longitudinal study"],"prefix":"10.1111","volume":"58","author":[{"given":"K.","family":"Antshel","sequence":"first","affiliation":[{"name":"Department of Psychology Syracuse University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Hier","sequence":"additional","affiliation":[{"name":"Department of Psychology Syracuse University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Fremont","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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