{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:06:52Z","timestamp":1770678412268,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T00:00:00Z","timestamp":1423785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The 22q11.2 deletion syndrome (22q11<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>; velo\u2010cardio\u2010facial syndrome) is associated with an increased risk of various disorders, including autism spectrum disorder (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>) and attention deficit hyperactivity disorder (<jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>). With this study, we aimed to investigate the relation between intellectual functioning and severity of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> symptomatology in 22q11<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A sample of 102 individuals (62 females) with 22q11<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> aged 9 to 18.5 years were assessed using age appropriate <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>echsler scales of intelligence as well as psychological and psychiatric assessment to evaluate the presence of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> symptomatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intelligence profiles were characterised by lower scores on the factor perceptual organisation and higher scores on the factor processing speed, with on subtest level higher scores on digit span and lower scores on arithmetic and vocabulary as compared with the mean factor or subtest score respectively. No differences in intelligence profiles were found between subgroups with and without <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>. Low scores on coding were associated with higher severity of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> symptomatology, while lower scores on block design were associated with more severe <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> symptomatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>On several sub\u2010domains of intelligence, poorer performance was associated with higher severity of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> symptomatology. The impact of developmental disorders in 22q11<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> can be traced in specific domains of intellectual functioning as well as in severity of symptomatology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12187","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T13:09:52Z","timestamp":1423832992000},"page":"803-815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intellectual functioning in relation to autism and <scp>ADHD<\/scp> symptomatology in children and adolescents with 22q11.2 deletion syndrome"],"prefix":"10.1111","volume":"59","author":[{"given":"E.","family":"Hidding","sequence":"first","affiliation":[{"name":"Department of Clinical Child and Adolescent Studies Faculty of Social and Behavioural Sciences Leiden University  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Swaab","sequence":"additional","affiliation":[{"name":"Department of Clinical Child and Adolescent Studies Faculty of Social and Behavioural Sciences and Leiden Institute of Brain and Cognition Leiden University  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M. J.","family":"de Sonneville","sequence":"additional","affiliation":[{"name":"Department of Clinical Child and Adolescent Studies Faculty of Social and Behavioural Sciences and Leiden Institute of Brain and Cognition Leiden University  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"van Engeland","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Brain Center Rudolph Magnus University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E. J.","family":"Sijmens\u2010Morcus","sequence":"additional","affiliation":[{"name":"Department of Clinical Child and Adolescent Studies Faculty of Social and Behavioural Sciences Leiden University  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. W. J.","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Psychology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. N.","family":"Duijff","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Brain Center Rudolph Magnus University Medical Centre Utrecht  Utrecht The Netherlands"},{"name":"Department of Pediatric Psychology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A. 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