{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:12:00Z","timestamp":1790507520344,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Ministry of Health","award":["(STPD11B8HM)"],"award-info":[{"award-number":["(STPD11B8HM)"]}]},{"name":"Italian Ministry of Health","award":["(F-2009-1530973)"],"award-info":[{"award-number":["(F-2009-1530973)"]}]},{"name":"Italian Ministry of Health","award":["\u201cProgetto strategico NEURAT\u201d from the Universi"],"award-info":[{"award-number":["\u201cProgetto strategico NEURAT\u201d from the Universi"]}]},{"name":"Italian Ministry of Health","award":["F-2009-1530973"],"award-info":[{"award-number":["F-2009-1530973"]}]},{"name":"University of Padua","award":["STPD11B8HM"],"award-info":[{"award-number":["STPD11B8HM"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to identify the mathematical domains affected in adults with neurofibromatosis 1 (NF1) and the impact of the numerical difficulties on the patients' activities of daily living.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed 28 adult patients with NF1 and 28 healthy control participants. All participants completed the standardised battery of numerical activities of daily living along with clinical batteries of cognitive (Mini\u2010Mental State Examination) and daily functioning (instrumental activities of daily living). The group comparisons of the performance on numerical activities of daily living were carried out using <jats:italic>t<\/jats:italic>\u2010test correcting for multiple comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that the NF1 group performed worse than controls in written subtractions, written multiplication, multiplication principles and digit comprehension (dot counting) tasks. Importantly, no significant differences in numerical ecological tasks were found between patients and controls, suggesting a possible use of compensatory strategies in daily living abilities in spite of calculation deficits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings indicate that NF1 affects calculation but not the basic comprehension or representation of numbers in adult patients. These data have important implications for designing cognitive interventions tailored to the cognitive profile of individuals with NF1.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12408","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T02:36:42Z","timestamp":1504060602000},"page":"1069-1077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Numerical activities of daily living in adults with neurofibromatosis type 1"],"prefix":"10.1111","volume":"61","author":[{"given":"F.","family":"Burgio","sequence":"first","affiliation":[{"name":"San Camillo Hospital IRCCS  Venice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Benavides\u2010Varela","sequence":"additional","affiliation":[{"name":"San Camillo Hospital IRCCS  Venice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Arcara","sequence":"additional","affiliation":[{"name":"San Camillo Hospital IRCCS  Venice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Trevisson","sequence":"additional","affiliation":[{"name":"Clinical Genetics Unit, Department of Women's and Children's Health University of Padova  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Frizziero","sequence":"additional","affiliation":[{"name":"Clinical Genetics Unit, Department of Women's and Children's Health University of Padova  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Clementi","sequence":"additional","affiliation":[{"name":"Clinical Genetics Unit, Department of Women's and Children's Health University of Padova  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Semenza","sequence":"additional","affiliation":[{"name":"San Camillo Hospital IRCCS  Venice Italy"},{"name":"Department of Neuroscience (Padova Neuroscience Centre) University of Padova  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-996-0036-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.05.031"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2016.12.014"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2016.01.011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2004.00634.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2003.07.008"},{"key":"e_1_2_8_8_1","volume-title":"The Oxford Handbook of Numerical Cognition (Vol 1)","author":"Cappelletti M.","year":"2015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0026328"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(01)00035-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15326942DN1701_02"},{"key":"e_1_2_8_12_1","first-page":"83","article-title":"Towards an anatomical and functional model of number processing","volume":"1","author":"Dehaene S.","year":"1995","journal-title":"Mathematical cognition"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2012.01648.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(96)00022-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000179303.72345.ce"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/9.3_Part_1.179"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2006.01.006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/002221940103400605"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-0277(92)90052-J"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.53"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380201700811"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00386"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15326942dn2903_8"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297049.2010.542746"},{"key":"e_1_2_8_25_1","volume-title":"Neurofibromatosis: phenotype, natural history, and pathogenesis","author":"Riccardi V. 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