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Yet, a cross\u2010syndrome comparison of these abilities between individuals with these two syndromes with known social deficits has not been conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010two children participated in four study groups: WS (<jats:italic>n<\/jats:italic>\u00a0=\u00a018), 22q112.DS (<jats:italic>n<\/jats:italic>\u00a0=\u00a024), age\u2010matched individuals with idiopathic developmental disability (IDD; <jats:italic>n<\/jats:italic>\u00a0=\u00a020) and typically developing (TD) controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a020). Participants completed four socio\u2010cognitive tests: facial emotion recognition, mental state attribution, differentiating real from apparent emotions and trait inference based on motives and actions\u2010outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The current findings demonstrate that children with WS were better in labelling happy faces compared with children with 22q11.2DS, partially reflecting their exaggerated social drive. In the false belief task, however, the WS and IDD groups performed poorly compared with the 22q11.2DS group, possibly due to their difficulty to interpret subtle social cues. When asked to identify the gap between real\u2010negative vs. apparent\u2010positive emotions, the 22q11.2DS group performed similarly to TD children but better than the WS group, possibly due to their anxious personality and their innate bias towards negatively valence cues. Finally, individuals with WS were more willing to become friends with a story character even when the character's motives were negative, reflecting their difficulty to avoid potentially harmful real\u2010life situations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, our multi\u2010facet socio\u2010cognitive battery uncovered strengths and weaknesses in social cognition that are syndrome\u2010specific, shared among the genetic syndromes, or common to the three clinical groups compared with healthy controls. Our findings underscore the need to devise age\u2010specific and condition\u2010specific assessment tools and intervention programs towards improving these children's socio\u2010cognitive deficits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12424","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T04:18:38Z","timestamp":1507522718000},"page":"1083-1093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparing the broad socio\u2010cognitive profile of youth with Williams syndrome and 22q11.2 deletion syndrome"],"prefix":"10.1111","volume":"61","author":[{"given":"O.","family":"Weisman","sequence":"first","affiliation":[{"name":"The Behavioral Neurogenetics Center The Edmond and Lily Safra Children's Hospital, Sheba Medical Center  Tel Hashomer Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5048-1381","authenticated-orcid":false,"given":"R.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Psychology and Gonda Brain Research Center Bar\u2010Ilan University  Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Burg\u2010Malki","sequence":"additional","affiliation":[{"name":"The Behavioral Neurogenetics Center The Edmond and Lily Safra Children's Hospital, Sheba Medical Center  Tel Hashomer Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Keren","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Child and Adolescent Division Geha Mental Health Center  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5724-2153","authenticated-orcid":false,"given":"R.","family":"Geva","sequence":"additional","affiliation":[{"name":"Department of Psychology and Gonda Brain Research Center Bar\u2010Ilan University  Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Diesendruck","sequence":"additional","affiliation":[{"name":"Department of Psychology and Gonda Brain Research Center Bar\u2010Ilan University  Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gothelf","sequence":"additional","affiliation":[{"name":"The Behavioral Neurogenetics Center The Edmond and Lily Safra Children's Hospital, Sheba Medical Center  Tel Hashomer Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.02.022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1866-1955-7-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00715"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780199692972.001.0001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.23.4.447.1228"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Williams syndrome: an unusual neuropsychological profile","author":"Bellugi U.","year":"1994","journal-title":"Atypical Cognitive Deficits in Developmental Disorders: Implications for Brain Function"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.1.101"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/02699200701541433"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0096-1523.26.2.527"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2009.06.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12183"},{"key":"e_1_2_8_13_1","first-page":"14","article-title":"Interpersonal Reactivity Index","volume":"10","author":"Davis M. 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