{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:11:25Z","timestamp":1774465885547,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Catatonia\u2010like presentations in people with autism have been increasingly recognised within research and diagnostic guidelines. The recently developed Attenuated Behaviour Questionnaire has identified that attenuated behaviour [autistic catatonia] is very prevalent in people with autism spectrum disorders (ASDs) and associated with repetitive behaviour. In the current study, we investigated attenuated behaviour within two genetic syndromes associated with ASD and examined ASD and repetitive behaviour as longitudinal predictors of attenuated behaviour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The Attenuated Behaviour Questionnaire was completed by parents\/carers of 33 individuals with Cornelia de Lange syndrome (CdLS) and 69 with fragile X syndrome (FXS). Information collected from the same informants 4\u00a0years previously was utilised to examine ASD and repetitive behaviour as predictors of later attenuated behaviour, controlling for age, gender and ability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Catatonia\u2010like attenuated behaviour was reported for individuals with CdLS (30.3%) and FXS (11.6%). Slowed movement was more prevalent in people with CdLS. No other phenotypic differences were observed. Across the two groups, repetitive behaviour predicted the presence of attenuated behaviour 4\u00a0years later, after controlling for age, gender and ability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Attenuated behaviour can be identified in individuals with CdLS and FXS and may have an effect on both adaptive behaviour and quality of life. Repetitive behaviours predicted subsequent risk within both groups and should be assessed by services as part of a pro\u2010active strategy of support.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12481","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T11:30:21Z","timestamp":1521113421000},"page":"486-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Attenuated behaviour in Cornelia de Lange and fragile X syndromes"],"prefix":"10.1111","volume":"62","author":[{"given":"L.","family":"Bell","sequence":"first","affiliation":[{"name":"Sefton Learning Disabilities Community Team Mersey Care NHS Trust  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Oliver","sequence":"additional","affiliation":[{"name":"Cerebra Centre for Neurodevelopmental Disorders, School of Psychology University of Birmingham  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wittkowski","sequence":"additional","affiliation":[{"name":"Division of Psychology &amp; Mental Health University of Manchester  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Moss","sequence":"additional","affiliation":[{"name":"Cerebra Centre for Neurodevelopmental Disorders, School of Psychology University of Birmingham  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1979-204X","authenticated-orcid":false,"given":"D.","family":"Hare","sequence":"additional","affiliation":[{"name":"School of Psychology, Cardiff University  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33964"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1749"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2010.01337.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.2003.00447.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.175.5.444"},{"key":"e_1_2_6_8_1","volume-title":"An Empirical Investigation into Autistic Catatonia: The Development of the Autistic Catatonia Questionnaire (ACQ) MPhil thesis","author":"Breen J.","year":"2014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12362"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470720"},{"key":"e_1_2_6_11_1","first-page":"42","article-title":"Katatonia: a new conceptual understanding of Catatonia and a new rating scale","volume":"5","author":"Carroll B.","year":"2008","journal-title":"Psychiatry"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(89)80004-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31438"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2015.12.003"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.115018"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-014-2085-y"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1352\/0895-8017(2004)109<275:SPIIWS>2.0.CO;2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1866-1955-6-10"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361304042722"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2008.07.014"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700054271"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02212936"},{"key":"e_1_2_6_23_1","volume-title":"Autism Diagnostic Observation Schedule","author":"Lord C.","year":"2012"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2009.01197.x"},{"key":"e_1_2_6_25_1","volume-title":"The Repetitive Behaviour Scale. 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