{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:24:27Z","timestamp":1778516667833,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001262","name":"Baily Thomas Charitable Fund","doi-asserted-by":"publisher","award":["3749\/6534"],"award-info":[{"award-number":["3749\/6534"]}],"id":[{"id":"10.13039\/501100001262","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>People with intellectual disabilities (IDs) have very high rates of osteoporosis and fractures, to which their widespread vitamin D deficiency and other factors could contribute. We aimed to assess in people with IDs previously treated for vitamin D deficiency (1) long\u2010term adherence to vitamin D supplementation and (2) bone mineral density (BMD), as an indicator for risk of fractures, according to vitamin D supplementation and other factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We recorded height, weight, medical, pharmacological, dietary and lifestyle assessment. Blood sample were taken for vitamin D and related analytes. dual\u2010energy X\u2010ray absorptiometry for BMD was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 51 study participants (mean [standard deviation, SD] age 51.5 [13.6] years, 57% male), 41 (80.4%) were taking vitamin D and 10 were not. Mean [SD] serum vitamin D was 81.3 [21.3] vs. 25.2 [10.2] nmol\/L (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), respectively. Thirty\u2010six participants underwent a dual\u2010energy X\u2010ray absorptiometry scan, which showed osteoporosis in 23.7% and osteopenia in 52.6%. Participants on vitamin D had higher BMD than those who were not, a statistically significant difference when confounders (lack of mobility and hypogonadism) were removed. BMD was significantly different according to mobility, particularly in wheelchair users, in whom hip BMD was 33% lower (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) than in participants with normal mobility. Participants still taking vitamin D showed a 6.1% increase in BMD at the spine (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) after mean [SD] 7.4 [1.5] years vitamin D treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In people with IDs and previous vitamin D deficiency, BMD increases on long\u2010term vitamin D supplementation. However, additional strategies must be considered for osteoporosis and fracture prevention in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12581","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T05:19:51Z","timestamp":1545283191000},"page":"357-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Vitamin <scp>D<\/scp>, bone mineral density and risk of fracture in people with intellectual disabilities"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8177-8778","authenticated-orcid":false,"given":"V.","family":"Frighi","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Oxford  Oxford UK"},{"name":"Learning Disabilities Oxford Health NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5832-7992","authenticated-orcid":false,"given":"A.","family":"Morovat","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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