{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:48:08Z","timestamp":1776091688472,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Persons with Down syndrome (DS) are at increased risk of developing Alzheimer's dementia (DS\u2010AD). Due to heterogeneity in the functioning in persons with DS, it is difficult to use cognitive testing to assess whether a person with DS has developed dementia due to AD. Electroencephalography (EEG) functional connectivity has shown promising results as a diagnostic tool for AD in persons without DS. In the current exploratory study, we investigated whether EEG functional connectivity could be used as a diagnostic marker of AD in persons with DS and the association with symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electroencephalography from 12 persons with DS and 16 persons with DS\u2010AD were analysed, and both coherence and weighted phase lag index were calculated. In addition, we calculated the average coherence for fronto\u2010parietal and temporo\u2010parietal connections. Lastly, we investigated the correlation between the informant\u2010based Dementia Screening Questionnaire in Intellectual Disability (DSQIID) and total alpha coherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Decreased alpha and increased delta coherence and weighted phase lag index were observed in DS\u2010AD as compared with DS. The decrease in alpha coherence was more marked in the fronto\u2010parietal connections as compared with the temporo\u2010parietal connections. No significant correlation was found between DSQIID and total alpha coherence (<jats:italic>P<\/jats:italic> value\u00a0=\u00a00.095, rho\u00a0=\u00a0\u22120.335).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The decreased alpha coherence and weighted phase lag index have previously been found in AD. The increased delta coherence and weighted phase lag index may indicate a different initial neurophysiological presentation as compared with patients with AD or may be a sign of more advanced disease. Larger studies are needed to confirm the current findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12803","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T16:39:54Z","timestamp":1608309594000},"page":"236-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Electroencephalographic functional connectivity is altered in persons with Down syndrome and Alzheimer's disease"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6442-2910","authenticated-orcid":false,"given":"C. S.","family":"Musaeus","sequence":"first","affiliation":[{"name":"Department of Neurology, Danish Dementia Research Centre (DDRC), Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. C.","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Dementia Research Centre (DDRC), Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. W.","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Neurophysiology Center Zealand University Hospital  Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Waldemar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Dementia Research Centre (DDRC), Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen 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