{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:55:27Z","timestamp":1768928127609,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009157","name":"National Institute on Disability, Independent Living, and Rehabilitation Research","doi-asserted-by":"publisher","award":["90IF0096\u201001\u201000"],"award-info":[{"award-number":["90IF0096\u201001\u201000"]}],"id":[{"id":"10.13039\/100009157","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infants with Down syndrome (DS) are at risk for a range of phenotypic outcomes, including delays in the onset of reaching behaviour, a critical skill that facilitates early learning. This parallel\u2010group feasibility and pilot study presents findings from a parent\u2010mediated micro\u2010intervention that aimed to support the development of reaching behaviour in a sample of infants with DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were 73 infants with DS and their caregivers. Infants who qualified for the home\u2010based intervention (based on manual skill performance on Bayley Scales of Infant and Toddler Development, Third Edition items) were randomly assigned individually or by geographical region to a treatment or an alternative treatment condition that involved toy\u2010based interactions with caregivers. Infants in the treatment condition experienced facilitated reaching during the toy\u2010based interactions through the use of Velcro\u2010affixed mittens and toys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two infants met criteria to participate in the intervention, and 37 participated in both baseline and post\u2010treatment visits. At post\u2010treatment, infants in the treatment condition demonstrated shorter latencies to make contact with objects and showed higher frequencies of reach attempts and swats at objects than infants in the alternative treatment group. These findings were more pronounced when examining a chronological age\u2010restricted subgroup of infants 5 to 10\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings suggest that a syndrome\u2010informed approach to targeted intervention may be a promising application of phenotyping science in DS and other neurogenetic conditions associated with intellectual disability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12814","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T04:44:29Z","timestamp":1612154669000},"page":"320-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Feasibility of a syndrome\u2010informed micro\u2010intervention for infants with Down syndrome"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6208-456X","authenticated-orcid":false,"given":"D. 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