{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:08:03Z","timestamp":1787166483701,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS P118\/00111"],"award-info":[{"award-number":["FIS P118\/00111"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["DPI2017\u201083989\u2010R"],"award-info":[{"award-number":["DPI2017\u201083989\u2010R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020\u2010117751RB\u2010I00"],"award-info":[{"award-number":["PID2020\u2010117751RB\u2010I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Knowledge regarding neuropsychological training in Rett syndrome (RS) is scarce. The aim of this study was to assess the outcome and the duration of the effect of cognitive stimulation on topographic electroencephalography (EEG) data in RS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty female children diagnosed with RS were included in the analysis. Girls with RS conducted a cognitive task using an eye\u2010tracker designed to evaluate access and choice skills. EEG data were acquired during the experimental procedure including two 10\u2010min baseline stages before and after the task. Topographical changes of several EEG spectral markers including absolute and relative powers, Brain Symmetry Index and entropy were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Topographic significance probability maps suggested statistical decreases on delta activity and increases on beta rhythm associated with the cognitive task. Entropy increased during and after the task, likely related to more complex brain activity. A significant positive interaction was obtained between Brain Symmetry Index and age showing that the improvement of interhemispheric symmetry was higher in younger girls (5\u201310\u00a0years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>According to our findings, significant alterations of brain rhythms were observed during and after cognitive stimulation, suggesting that cognitive stimulation may have effects on brain activity beyond the stimulation period. Finally, our promising results also showed an increase brain symmetry that was especially relevant for the younger group. This could suggest an interaction of the eye\u2010tracking cognitive task; however, further studies in this field are needed to assess the relation between brain asymmetries and age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jir.12902","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T02:33:40Z","timestamp":1637289220000},"page":"213-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cognitive stimulation has potential for brain activation in individuals with Rett syndrome"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2781-8841","authenticated-orcid":false,"given":"C.","family":"Migliorelli","sequence":"first","affiliation":[{"name":"Department of Automatic Control (ESAII), Biomedical Engineering Research Centre (CREB) Universitat Polit\u00e8cnica de Catalunya (UPC)  Barcelona Spain"},{"name":"CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER\u2010BBN)  Madrid Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Medina\u2010Rivera","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Neurology Department, Neurometabolic Unit and Synaptic Metabolism Lab, Institut Pedi\u00e0tric de Recerca Hospital Sant Joan de D\u00e9u, metabERN and CIBERER\u2010ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-1027","authenticated-orcid":false,"given":"A.","family":"Bachiller","sequence":"additional","affiliation":[{"name":"Department of Automatic Control (ESAII), Biomedical Engineering Research Centre (CREB) Universitat Polit\u00e8cnica de Catalunya (UPC)  Barcelona Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9821-1460","authenticated-orcid":false,"given":"A.","family":"Tost","sequence":"additional","affiliation":[{"name":"Department of Automatic Control (ESAII), Biomedical Engineering Research Centre (CREB) Universitat Polit\u00e8cnica de Catalunya (UPC)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2980-6716","authenticated-orcid":false,"given":"J. F.","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Automatic Control (ESAII), Biomedical Engineering Research Centre (CREB) Universitat Polit\u00e8cnica de Catalunya (UPC)  Barcelona Spain"},{"name":"CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER\u2010BBN)  Madrid Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8657-3779","authenticated-orcid":false,"given":"A.","family":"L\u00f3pez\u2010Sala","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Neurology Department, Neurometabolic Unit and Synaptic Metabolism Lab, Institut Pedi\u00e0tric de Recerca Hospital Sant Joan de D\u00e9u, metabERN and CIBERER\u2010ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0588-9307","authenticated-orcid":false,"given":"J.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Molecular Genetics Medicine Section Hospital Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1896-1622","authenticated-orcid":false,"given":"M. d. M.","family":"O'Callahan","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Neurology Department, Neurometabolic Unit and Synaptic Metabolism Lab, Institut Pedi\u00e0tric de Recerca Hospital Sant Joan de D\u00e9u, metabERN and CIBERER\u2010ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6817-9807","authenticated-orcid":false,"given":"M.","family":"Pineda","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9836-6083","authenticated-orcid":false,"given":"M. A.","family":"Ma\u00f1anas","sequence":"additional","affiliation":[{"name":"Department of Automatic Control (ESAII), Biomedical Engineering Research Centre (CREB) Universitat Polit\u00e8cnica de Catalunya (UPC)  Barcelona Spain"},{"name":"CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER\u2010BBN)  Madrid Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8627-543X","authenticated-orcid":false,"given":"S.","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Automatic Control (ESAII), Biomedical Engineering Research Centre (CREB) Universitat Polit\u00e8cnica de Catalunya (UPC)  Barcelona Spain"},{"name":"CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER\u2010BBN)  Madrid Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9853-688X","authenticated-orcid":false,"given":"\u00c1.","family":"Garc\u00eda\u2010Cazorla","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Neurology Department, Neurometabolic Unit and Synaptic Metabolism Lab, Institut Pedi\u00e0tric de Recerca Hospital Sant Joan de D\u00e9u, metabERN and CIBERER\u2010ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knosys.2015.08.004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2017.09.010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci-2018-0017"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(92)90002-L"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-014-0488-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-002-0396-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2006.00818.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2011.05.006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2013.11.004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.05.004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12228"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.71.021906"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9816591"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2012.04.009"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2016.01.009"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.7358\/neur-2018-024-fabi"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10050276"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2021.103891"},{"key":"e_1_2_10_21_1","first-page":"47","article-title":"Choice behavior in Rett Syndrome: the consistency parameter","volume":"21","author":"Fabio R. A.","year":"2018","journal-title":"Life Span and Disability"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq071"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.91.2.445"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(01)00349-7"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24457"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.10020"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.6001\/actamedica.v25i2.3763"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00003"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-013-1909-5"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2010.00200"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22124"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000308"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.12.030"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-019-9275-z"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2016.01.015"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1650"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X20150033"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2008.09.006"},{"key":"e_1_2_10_39_1","first-page":"199","volume-title":"Major Psychological Assessment Instruments","author":"Sparrow S. S.","year":"1989"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.05.005"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073888003001S03"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2003.12.002"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.01.024"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2003.10.012"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055347"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000341"}],"container-title":["Journal of Intellectual Disability Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jir.12902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jir.12902","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jir.12902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T12:42:55Z","timestamp":1693226575000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jir.12902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,18]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/jir.12902"],"URL":"https:\/\/doi.org\/10.1111\/jir.12902","archive":["Portico"],"relation":{},"ISSN":["0964-2633","1365-2788"],"issn-type":[{"value":"0964-2633","type":"print"},{"value":"1365-2788","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,18]]},"assertion":[{"value":"2020-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}