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To better characterise heterogeneity in ASD symptomatology in DS, profiles of caregiver\u2010reported ASD symptoms were modelled for children and adolescents with DS. Methods: Participants (<jats:italic>n<\/jats:italic> = 125) were recruited through several multi\u2010site research studies on cognition and language in DS. Using the Social Responsiveness Scale\u20102 (SRS\u20102; Constantino and Gruber 2012), two latent profile analyses (LPA) were performed, one on the broad composite scores of social communication and interaction and restricted interests and repetitive behaviour, and a second on the four social dimensions of social communication, social motivation, social awareness, and social cognition. Results: A three\u2010profile model was the best fit for both analyses, with each analysis yielding a low ASD symptom profile, an elevated or mixed ASD symptom profile and a high ASD symptom profile. Associations were observed between profile probability scores and IQ, the number of co\u2010occurring biomedical conditions reported, sex, and SRS\u20102 form. Conclusions: Characterising heterogeneity in ASD symptom profiles can inform more personalised supports in this population, and implications for potential therapeutic approaches for individuals with DS are discussed.<\/jats:p>","DOI":"10.1111\/jir.12910","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T07:32:31Z","timestamp":1641367951000},"page":"265-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Latent profiles of autism symptoms in children and adolescents with Down syndrome"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6208-456X","authenticated-orcid":false,"given":"D. 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