{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:11:21Z","timestamp":1777367481412,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["5K99HD092606"],"award-info":[{"award-number":["5K99HD092606"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Individuals with Down syndrome (DS) have low levels of cardiorespiratory fitness and previous studies have shown that these low levels of fitness have a physiological cause. During exercise, the cardiovascular, ventilatory and muscular systems are simultaneously active. While individual parameters of these systems have been investigated in DS before, the interaction between these parameters and systems have not been discussed in detail. Doing so may provide important insight regarding the aetiology of low cardiorespiratory fitness and which parameters of the cardiovascular, pulmonary and muscular systems are altered in individuals with DS compared with their peers without DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cardiopulmonary exercise tests were performed in healthy adults with and without DS. Parameters related to the cardiovascular, ventilatory and muscular systems were collected until VO<jats:sub>2peak<\/jats:sub>. In total, 51 participants were included in analysis, of which 21 had DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals with DS showed lower peak values for all collected outcomes (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.001) compared with those without DS, except for ventilatory threshold as a percentage of maximal oxygen uptake and V<jats:sub>E<\/jats:sub>\/VCO<jats:sub>2<\/jats:sub> slope, which were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results show that individuals with DS present impairments across the cardiovascular, ventilatory and muscular aspects of the cardiopulmonary system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12954","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T08:00:08Z","timestamp":1655971208000},"page":"978-987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comprehensive cardiopulmonary profile of individuals with Down syndrome"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2310-3331","authenticated-orcid":false,"given":"V. D. Y.","family":"Beck","sequence":"first","affiliation":[{"name":"Department of Physical Therapy University of Nevada \u2010 Las Vegas  Las Vegas NV USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3485-4405","authenticated-orcid":false,"given":"S. O.","family":"Wee","sequence":"additional","affiliation":[{"name":"Department of Kinesiology California State University San Bernardino  San Bernardino CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. C.","family":"Lefferts","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Iowa State University  Ames IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. A.","family":"Hibner","sequence":"additional","affiliation":[{"name":"Integrative Physiology Laboratory, College of Applied Health Sciences University of Illinois at Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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