{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:58:21Z","timestamp":1771037901959,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"8-9","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001588","name":"Donors Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001588","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001673","name":"Fondation J\u00e9r\u00f4me Lejeune","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adults with Down syndrome (DS) are at increased risk of developing Alzheimer's disease (AD) due to genetic predisposition. Identification of patients with AD is difficult since intellectual disabilities (ID) may confound diagnosis. The objective of this study was to evaluate the ability of the French version of the modified cued recall test (mCRT) to distinguish between subjects with and without AD in the adult DS population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective, single\u2010centre, medical records study including data between March 2014 and July 2020. Adults aged \u226530\u00a0years with DS who had at least one mCRT record available were eligible. Age, sex and ID level were extracted, and subjects were attributed to three groups: patients with AD, patients with co\u2010occurring conditions that may impact cognitive function and subjects without AD. mCRT scores, adjusted by sex, age and ID level, were compared between groups. The optimal cut\u2010off value to distinguish between patients with and without AD was determined using the receiver operating characteristic curve. The impact of age and ID level on mCRT scores was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 194 patients with DS were included: 12 patients with AD, 94 patients with co\u2010occurring conditions and 88 healthy subjects. Total recall scores were significantly lower (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) in patients with AD compared with healthy subjects. The optimal cut\u2010off value to discriminate between patients with AD and healthy subjects was 22, which compares well with the cut\u2010off value of 23 originally reported for the English version of the mCRT. Patients aged 30\u201344\u00a0years had higher mCRT total recall scores compared with patients aged \u226545\u00a0years (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0221). Similarly, patients with mild ID had higher mCRT scores compared with patients with severe ID (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The mCRT is a sensitive tool that may help in the clinical diagnosis of AD in subjects with DS. Early recognition of AD is paramount to deliver appropriate interventions to this vulnerable population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12957","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T08:56:06Z","timestamp":1655801766000},"page":"690-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Modified cued recall test in the French population with Down syndrome: A retrospective medical records analysis"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1712-7852","authenticated-orcid":false,"given":"S.","family":"Sacco","sequence":"first","affiliation":[{"name":"Institut J\u00e9r\u00f4me Lejeune  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Falquero","sequence":"additional","affiliation":[{"name":"Institut J\u00e9r\u00f4me Lejeune  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bouis","sequence":"additional","affiliation":[{"name":"Institut J\u00e9r\u00f4me Lejeune  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Akkaya","sequence":"additional","affiliation":[{"name":"Institut J\u00e9r\u00f4me Lejeune  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gallard","sequence":"additional","affiliation":[{"name":"Institut J\u00e9r\u00f4me Lejeune  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pichot","sequence":"additional","affiliation":[{"name":"Institut J\u00e9r\u00f4me Lejeune  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Radice","sequence":"additional","affiliation":[{"name":"Institut J\u00e9r\u00f4me Lejeune  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bazin","sequence":"additional","affiliation":[{"name":"Department of Statistics eXYSTAT  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Montestruc","sequence":"additional","affiliation":[{"name":"Department of Statistics eXYSTAT  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hiance\u2010Delahaye","sequence":"additional","affiliation":[{"name":"Institut J\u00e9r\u00f4me Lejeune  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.\u2010S.","family":"Rebillat","sequence":"additional","affiliation":[{"name":"Institut J\u00e9r\u00f4me Lejeune  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317519841191"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216221"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944-7558-120.6.481"},{"key":"e_1_2_10_5_1","first-page":"1","article-title":"Diagnosis of prodromal and Alzheimer's disease dementia in adults with Down syndrome using neuropsychological tests","volume":"12","author":"Benejam B.","year":"2020","journal-title":"Alzheimers Dement. 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