{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:57:20Z","timestamp":1783468640042,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005668","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","doi-asserted-by":"publisher","award":["FAPDF 193.001607\/2017"],"award-info":[{"award-number":["FAPDF 193.001607\/2017"]}],"id":[{"id":"10.13039\/501100005668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low muscle quality index (MQI) is a potential risk of developing functional impairments in older people. However, considering that individuals with Down syndrome (DS) present with a faster decline in biological aging, an investigation on MQI in individuals with DS is necessary. The aims of this present cross\u2010sectional study were to compare (1) MQI between adolescents with and without DS and (2) evaluate laboratory versus field\u2010based estimates of MQI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010six adolescents were recruited and separated into two groups: DS (<jats:italic>n<\/jats:italic>\u00a0=\u00a030, 13 boys and 17 girls; age: 12.38\u00a0\u00b1\u00a03.07\u00a0years) and a control (non\u2010DS; <jats:italic>n<\/jats:italic>\u00a0=\u00a026, 9 boys and 17 girls; age: 12.46\u00a0\u00b1\u00a02.88\u00a0years). Laboratory MQI was derived from the ratio of grip strength to arm muscle mass (in kg) measured by dual\u2010energy X\u2010ray absorptiometry (DXA). Field\u2010based MQI was quantified from the ratio of hand grip strength (HGS) to body mass index (BMI). For statistical analyses, a two\u2010way ANOVA was conducted for group comparisons, and a Pearson correlation was used to test the association between field MQI and laboratory MQI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adolescents with DS displayed lower field (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), laboratory MQI estimates (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and HGS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) as compared non\u2010DS. Also, there was a strong correlation effect between field MQI and laboratory MQI estimates (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, <jats:italic>R<\/jats:italic>\u00a0=\u00a00.81).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adolescents with DS have lower field and laboratory MQI compared with adolescents without DS. Simpler field MQI might be used in daily clinical practice, with special attention to those with DS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12959","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T08:20:34Z","timestamp":1655972434000},"page":"1000-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Field\u2010based versus laboratory\u2010based estimates of muscle quality index in adolescents with and without Down syndrome"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-2212","authenticated-orcid":false,"given":"G. L. R.","family":"Melo","sequence":"first","affiliation":[{"name":"Department of Physical Education Catholic University of Bras\u00edlia  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Moraes","sequence":"additional","affiliation":[{"name":"Department of Physical Education Catholic University of Bras\u00edlia  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. F.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Department of Physical Education Catholic University of Bras\u00edlia  Bras\u00edlia Brazil"},{"name":"Department of Physical Education Secretary of the State of Education of the Federal District  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1940-8690","authenticated-orcid":false,"given":"E. M.","family":"Boato","sequence":"additional","affiliation":[{"name":"Department of Physical Education Secretary of the State of Education of the Federal District  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. L. R.","family":"Beal","sequence":"additional","affiliation":[{"name":"Department of Gerontology Catholic University of Bras\u00edlia  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-5350","authenticated-orcid":false,"given":"W.","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of School of Kinesiology Recreation and Sport Western Kentucky University  Bowling Green FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6580-9404","authenticated-orcid":false,"given":"D.","family":"da Cunha Nascimento","sequence":"additional","affiliation":[{"name":"Department of Physical Education Catholic University of Bras\u00edlia  Bras\u00edlia Brazil"},{"name":"Department of Gerontology Catholic University of Bras\u00edlia  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103483"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/0014013042000327724"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.12.008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.06.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-012-0004-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2012.06.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2016.06.018"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2011.06.032"},{"key":"e_1_2_9_10_1","first-page":"287","article-title":"Ultrastructural features of skeletal muscle in adult and aging Ts65Dn mice, a murine model of Down syndrome","volume":"3","author":"Cisterna B.","year":"2013","journal-title":"Muscles, ligaments and tendons journal"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S143192762002437X"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.01.028"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu039"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(99)00178-X"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MRR.0000000000000147"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00312.2012"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181b07e7a"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.12965\/jer.2040668.334"},{"key":"e_1_2_9_19_1","unstructured":"Ferguson C. 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