{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:45:43Z","timestamp":1771494343552,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Angelman syndrome (AS) is a neurogenetic disorder that causes severe intellectual disability, expressive language deficits, motor impairment, ataxia, sleep problems, epileptic seizures and a happy disposition. People with AS frequently experience gastrointestinal (GI) symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This study used data from the Global Angelman Syndrome Registry to explore the relationship between early and current GI symptoms and co\u2010morbidity in children and adolescents with AS (<jats:italic>n<\/jats:italic>\u00a0=\u00a0173). Two groups that experienced a high (<jats:italic>n<\/jats:italic>\u00a0=\u00a091) and a low (<jats:italic>n<\/jats:italic>\u00a0=\u00a082) frequency of GI symptoms were examined in relation to feeding and GI history in infancy, sleep and toileting problems, levels of language and communication and challenging behaviours. Predictors of GI symptoms were then investigated using a series of logistic regressions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This analysis found that constipation and gastroesophageal reflux affected 84% and 64%, of the sample, respectively. The high frequency of GI symptoms were significantly associated with: \u2018refusal to nurse\u2019, \u2018vomiting\u2019, \u2018arching\u2019, \u2018difficulty gaining weight\u2019, gastroesophageal reflux, \u2018solid food transition\u2019, frequency of night\u2010time urinary continence and sleep hyperhidrosis during infancy. GI symptoms were not significantly associated with sleep, toileting, language or challenging behaviours. Significant predictors of high frequency GI symptoms were gastroesophageal reflux and sleep hyperhidrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Future research needs to investigate the association between AS and GI co\u2010morbidity in adults with AS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12975","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T08:39:59Z","timestamp":1662107999000},"page":"865-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association between early and current gastro\u2010intestinal symptoms and co\u2010morbidities in children and adolescents with Angelman syndrome"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8719-0617","authenticated-orcid":false,"given":"G.","family":"Leader","sequence":"first","affiliation":[{"name":"Irish Centre for Autism and Neurodevelopmental Research, School of Psychology National University of Ireland  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9794-6246","authenticated-orcid":false,"given":"S.","family":"Whelan","sequence":"additional","affiliation":[{"name":"Irish Centre for Autism and Neurodevelopmental Research, School of Psychology National University of Ireland  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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