{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:18:24Z","timestamp":1791497904215,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR002368"],"award-info":[{"award-number":["TL1TR002368"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adolescents with Down syndrome (DS) are two to three times more likely to be obese than their typically developing peers. When preventing or treating obesity, it is useful for clinicians to understand an individual's energy intake needs. Predictive resting energy expenditure (REE) equations are often recommended for general use in energy intake recommendations; however, these predictive equations have not been validated in youth with DS. The aim of this study was to compare the accuracy of seven commonly used predictive equations for estimating REE in adolescents who are typically developing to REE measured by indirect calorimetry in adolescents with DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adolescents with DS participated in a 90\u2010min laboratory visit before 10:00\u00a0a.m. after a 12\u2010h overnight fast and a 48\u2010h abstention from aerobic exercise. REE was measured via indirect calorimetry, and estimated REE was derived using the Institute of Medicine, Molnar, Muller and World Health Organization equations. Mean differences between the measured and predicted REE for each equation were evaluated with equivalency testing, and <jats:italic>P<\/jats:italic>\u2010values were adjusted for multiple comparisons using the Holm method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six adolescents with DS (age: 15.5\u00a0\u00b1\u00a01.7\u00a0years, 47.8% female, 73.9% non\u2010Hispanic White) completed the REE assessment. Average measured REE was 1459.5\u00a0\u00b1\u00a0267.8\u00a0kcal\/day, and the Institute of Medicine equations provided the most accurate prediction of REE with a 1.7\u00a0\u00b1\u00a011.2% (13.9\u00a0\u00b1\u00a0170.3\u00a0kcal\/day) overestimation. This prediction was not statistically different from the measured REE [<jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00.582; 95% confidence interval (CI): \u221264.5, 36.7], and the difference between the measured and predicted REE was statistically equivalent to zero (<jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00.024; 90% CI: \u221256.1, 28.3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest that the Institute of Medicine equation may be useful in predicting REE in adolescents with DS. Future research should confirm these results in a larger sample and determine the utility of the Institute of Medicine equation for energy intake recommendations during a weight management intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12995","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:29:06Z","timestamp":1669336146000},"page":"112-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Resting energy expenditure in adolescents with Down syndrome: a comparison of commonly used predictive equations"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3362-3581","authenticated-orcid":false,"given":"B. C.","family":"Helsel","sequence":"first","affiliation":[{"name":"University of Kansas Alzheimer's Disease Research Center, Department of Neurology The University of Kansas Medical Center  Fairway KS USA"},{"name":"Center for Children's Healthy Lifestyles &amp; Nutrition Children's Mercy Kansas City and The University of Kansas Medical Center  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. P.","family":"Shook","sequence":"additional","affiliation":[{"name":"Center for Children's Healthy Lifestyles &amp; Nutrition Children's Mercy Kansas City and The University of Kansas Medical Center  Kansas City MO USA"},{"name":"Department of Pediatrics Children's Mercy Kansas City  Kansas City MO USA"},{"name":"School of Medicine University of Missouri \u2013 Kansas City  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-6034","authenticated-orcid":false,"given":"B.","family":"Forseth","sequence":"additional","affiliation":[{"name":"Center for Children's Healthy Lifestyles &amp; Nutrition Children's Mercy Kansas City and The University of Kansas Medical Center  Kansas City MO USA"},{"name":"Department of Pediatrics The University of Kansas Medical Center  Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Dreyer Gillette","sequence":"additional","affiliation":[{"name":"Center for Children's Healthy Lifestyles &amp; Nutrition Children's Mercy Kansas City and The University of Kansas Medical Center  Kansas City MO USA"},{"name":"Department of Pediatrics Children's Mercy Kansas City  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Polfuss","sequence":"additional","affiliation":[{"name":"College of Nursing University of Wisconsin\u2010Milwaukee  Milwaukee WI USA"},{"name":"Department of Nursing Research and Evidence\u2010Based Practice Children's Wisconsin  Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Mercy Kansas City  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Posson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Mercy Kansas City  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Steele","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Kansas Medical Center  Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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