{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:23:45Z","timestamp":1784777025995,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Down syndrome (DS) generally predisposes children to a pattern of relative developmental strengths and challenges, but within\u2010syndrome heterogeneity is also commonly observed across many dimensions. The present research examines whether heterogeneity in developmental presentation can be detected during infancy in DS and whether factors associated with differing profiles can be identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants with DS (<jats:italic>n<\/jats:italic>\u00a0=\u00a075; age range: 3.9\u201317.6\u00a0months) were administered the Bayley Scales of Infant Development III (Bayley\u2010III). A primary caregiver provided information regarding developmental history and family demographics. Latent profile analysis was conducted to identify whether early profiles were present across the five Bayley\u2010III domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three developmental profiles were observable within the sample: a \u2018Mild Delay\u2019 Profile, an \u2018Moderate Delay\u2019 Profile and a \u2018Pronounced Delay\u2019 Profile. In addition, chronological age, having received heart surgery and having received occupational therapy were associated with probability of profile membership.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings from this study contribute to the growing knowledgebase regarding heterogenous presentations associated with DS and can inform early intervention planning.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.12997","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T11:10:48Z","timestamp":1670584248000},"page":"228-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Early developmental profiles among infants with Down syndrome"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6565-7500","authenticated-orcid":false,"given":"S.","family":"Onnivello","sequence":"first","affiliation":[{"name":"Department of Developmental Psychology and Socialization University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5309-339X","authenticated-orcid":false,"given":"E. K.","family":"Schworer","sequence":"additional","affiliation":[{"name":"Waisman Center University of Wisconsin\u2010Madison  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Prince","sequence":"additional","affiliation":[{"name":"Department of Psychology Colorado State University  Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"Daunhauer","sequence":"additional","affiliation":[{"name":"Human Development and Family Studies Colorado State University  Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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