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Despite the frequent use of the BRIEF2 for measuring executive functioning in individuals with Down syndrome, no study has investigated the factorial validity or dimensionality of the BRIEF2 in this population. This study aimed to address this notable gap in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Parents of 407 children and youth with Down syndrome aged 6\u201318\u00a0years completed the BRIEF2 as part of different studies led by six sites. Three competing models proposed by previous studies were analysed using Confirmatory Factor Analysis: the theoretical structure of the BRIEF2 where the scales were constrained to load on three factors labelled as Cognitive, Behavioral, and Emotional Regulation, a two\u2010factor correlated model with the merged Behavioral and Emotional regulation, and a single\u2010factor model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The three\u2010factor model provided a better fit than the one\u2010 and two\u2010factor models, yet a large correlation was observed between Behavioural and Emotional regulation factors. The results provide meaningful explanatory value for the theoretical structure of the BRIEF2. However, the Behavioral and Emotional regulation factors might be less differentiated and the two\u2010factor structure of the BRIEF2 may also make theoretical and empirical sense.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although more studies are needed to further examine the factor structure of the BRIEF2 in youth with Down syndrome, this investigation provides preliminary support for the interpretation of the three executive function index scores provided by the BRIEF2: Cognitive, Behavioral, and Emotional Regulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.13000","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T06:19:40Z","timestamp":1672121980000},"page":"148-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Confirmatory factor analysis of the BRIEF2 in a sample of youth with Down syndrome"],"prefix":"10.1111","volume":"67","author":[{"given":"A.","family":"Soltani","sequence":"first","affiliation":[{"name":"Department of Educational Psychology, Kerman Branch Islamic Azad University  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5309-339X","authenticated-orcid":false,"given":"E. 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