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Participants gave feedback and discussed the concept of health in DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Feedback from participants resulted in iterative refinement of our model, retaining the three dimensions of health, and modifying constructs within those dimensions. Experts and parents agreed that individuals with DS have unique health concerns that necessitate the creation and validation of a syndrome\u2010specific health model. We present key themes that we identified and a final conceptual model of health for individuals with DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Health in DS is a multi\u2010dimensional, multi\u2010construct model focused on relevant constructs of causal and effect indicators. This conceptual model can be used in future research to develop a syndrome\u2010specific measure of health status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.13007","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T04:11:43Z","timestamp":1674015103000},"page":"323-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Health in Down syndrome: creating a conceptual model"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4172-0288","authenticated-orcid":false,"given":"S. L.","family":"Santoro","sequence":"first","affiliation":[{"name":"Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics Massachusetts General Hospital  Boston MA USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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