{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:32:04Z","timestamp":1770330724849,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD101075\u201001"],"award-info":[{"award-number":["R21HD101075\u201001"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001744","name":"MAYDAY Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>As clinical trials for Rett syndrome are underway, there is a need to validate potential supplemental outcome measures that reflect important signs and symptoms.<\/jats:p><jats:p>Autonomic dysfunction, particularly vasomotor dysfunction, is one potential area for which biomarkers could be developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the current study, infrared thermal images of hands and feet from 26 females with Rett syndrome (aged 62\u00a0months to 39\u00a0years), and 17 females without known intellectual, genetic or neurological disorders (aged 55\u00a0months to 39\u00a0years) were collected. Between\u2010group differences in skin temperature, and temporal stability of skin temperature measures in the Rett syndrome group, and relationships between skin temperature measures and parent\u2010reported and researcher\u2010evaluated indicators of autonomic dysfunction were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between\u2010group differences showed lower hand and foot temperatures in the Rett syndrome group. Hand temperature measurements were stable over time and were moderately correlated with parent\u2010reported autonomic symptoms. Foot temperature measurements were more variable than hand temperatures but showed stronger correlations with parent\u2010reported autonomic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results provide preliminary support for the reliability and validity of hand and foot skin temperature measures in Rett syndrome. Additional research is needed to replicate these results and evaluate the temporal stability of these measures over shorter time scales.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.13010","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T09:49:03Z","timestamp":1675676943000},"page":"387-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preliminary assessment of the reliability and validity of infrared skin temperature measurements in Rett syndrome"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7645-1479","authenticated-orcid":false,"given":"B. J.","family":"Byiers","sequence":"first","affiliation":[{"name":"Department of Educational Psychology University of Minnesota  Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Merbler","sequence":"additional","affiliation":[{"name":"Department of Educational Psychology University of Minnesota  Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. C.","family":"Burkitt","sequence":"additional","affiliation":[{"name":"Gillette Children's Specialty Healthcare  St. Paul MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Beisang","sequence":"additional","affiliation":[{"name":"Gillette Children's Specialty Healthcare  St. Paul MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. J.","family":"Symons","sequence":"additional","affiliation":[{"name":"Department of Educational Psychology University of Minnesota  Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","unstructured":"Ammer K.(2019).Sources of uncertainty in the evaluation of thermal images in medicine. 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